| 血清白介素-6在诊断肝细胞肝癌中的临床价值研究 |
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| 引用本文： | 李清明,舒仁明,王家驷,白俊玺.血清白介素-6在诊断肝细胞肝癌中的临床价值研究[J].川北医学院学报,2011,26(3):251-253. |
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| 作者姓名： | 李清明 舒仁明 王家驷 白俊玺 |
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| 作者单位： | 四川省达州市中心医院,四川达州,635000;四川省达州市中心医院,四川达州,635000;四川省达州市中心医院,四川达州,635000;四川省达州市中心医院,四川达州,635000 |
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| 摘 要： | 目的:探索血清白介素-6(IL-6)在原发性肝细胞肝癌(HCC)诊断中的临床价值。方法:采用酶联免疫法(ELISA法)和电化学发光法分别测定30例原发性肝细胞肝癌患者、30例肝良性疾病患者血清白介素-6和甲胎蛋白(AFP)水平,并与30例正常对照组进行比较。结果:原发性肝细胞肝癌组患者血清IL-6水平(25.99±18.57 ng/L)及AFP水平(441.40±351.75μg/L)明显高于肝良性病组IL-6(9.09±7.44 ng/L)及AFP水平(86.86±58.64μg/L)和正常对照组IL-6(1.43±1.00 ng/L)及AFP水平(7.92±4.88μg/L),差异有统计学意义(p<0.05)。血清IL-6诊断原发性肝细胞肝癌的敏感性、特异性分别为83%、81%,而AFP的敏感性和特异性分别为63%、98%。二者联合检测时的敏感性、特异性则分别为90%,82%。结论:血清IL-6在原发性肝细胞肝癌的检测中敏感性明显高于AFP。若两项指标联合检测,可显著提高原发性肝细胞肝癌阳性检出率,有助于防止原发性肝细胞肝癌的漏诊。
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| 关 键 词： | 白介素-6 甲胎蛋白 肝细胞肝癌 肿瘤标志物 |
Clinical Value of Serum Interleukin - 6 in Diagnosing Primary Hepatocellular Carcinoma |
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| LI Qing-ming,SHU Ren-ming,WANG Jia-si,BAI Jun-xi.Clinical Value of Serum Interleukin - 6 in Diagnosing Primary Hepatocellular Carcinoma[J].Journal of North Sichuan Medical College,2011,26(3):251-253. |
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| Authors: | LI Qing-ming SHU Ren-ming WANG Jia-si BAI Jun-xi |
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| Institution: | LI Qing-ming,SHU Ren-ming,WANG Jia-si,BAI Jun-xi(The Central Hospital of Dazhou City,Dazhou City,Sichuan 635000) |
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| Abstract: | Objective: To investigate the clinical value of serum interleukin-6(IL-6) in diagnosing primary hepatocellular carcinoma.Methods:Serum IL-6,AFP was respectively measured by enzyme linked immunosorbent assay and chemiluminessant immunoassay in 30 patients with primary hepatocellular carcinoma,30 patients with benign liver disease and 30 normal subjects.Results:Serum IL-6,AFP levels were significantly increased in primary hepatocellular carcinoma(p<0.05).For diagnosing primary hepatocellular carcinoma,the sen... |
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| Keywords: | Interleukin-6 AFP Hepatocellular carcinoma Tumor marker |
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