| 破骨细胞的分化及可溶性因子调节 |
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| 引用本文： | 曾晓峰,赵建宁. 破骨细胞的分化及可溶性因子调节[J]. 医学研究生学报, 2003, 16(3): 215-218 |
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| 作者姓名： | 曾晓峰 赵建宁 |
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| 作者单位： | 南京军区南京总医院军区骨科中心,江苏南京,210002 |
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| 摘 要： | 破骨细胞起源于造血干细胞的粒细胞 巨噬细胞集落形成单位。在它的分化、融合和增生期均受到体内激素和多种可溶性细胞因子的调节 ,介导破骨细胞的骨吸收作用及其对各种细胞因子反应的信号传导通路 ,主要包括环磷酸腺苷 (cAMP)和受体酪氨酸激酶 (R PTK)。了解破骨细胞研究方面的新进展 ,将有助于临床更好地分析各种骨代谢性疾病的病因及发病机制 ,进而为治疗提供理论依据。
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| 关 键 词： | 破骨细胞 细胞因子 信号传导 |
| 文章编号： | 1008-8199(2003)03-0215-04 |
| 修稿时间： | 2002-01-21 |
Differentiation and regulation of the osteoclast |
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| ZENG Xiao feng reviewing,ZHAO Jian ning checking. Differentiation and regulation of the osteoclast[J]. Bulletin of Medical Postgraduate, 2003, 16(3): 215-218 |
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| Authors: | ZENG Xiao feng reviewing ZHAO Jian ning checking |
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| Abstract: | The osteoclast is a hematopoietic cell derived from CFU GM, which is regulated by systemic hormones, soluble factors in the phase of differentiation, fusion and proliferation. The major singnaling pathways involved in osteoclastic bone resorption and formation in response to cytokine and hormones include cAMP and R PTK. The advances in our understanding of the osteoclast make it possible for us to comprehend the development and the treatment of the bone metabolic diseases. |
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| Keywords: | Osteoclast Cytokine Signal transduction |
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