不稳定性心绞痛患者血清P选择素、可溶性细胞间粘附因子-1的变化及奥扎格雷对其影响

目的探讨Ps、SICAM-1在UAP患者中的作用及奥扎格雷对其影响。方法选择UAP患者49例,分为药物治疗组24例,非药物治疗组25例,正常对照组22例,药物治疗组给予奥扎格雷治疗。于治疗前、治疗后15天及正常对照组采肘静脉血,应用酶联免疫法测血清中Ps、SICAM-1。结果UAP患者血清中Ps、SICAM-1水平明显高于对照组。治疗15天后药物治疗组的Ps、SICAM-1水平明显低于非药物治疗组。结论Ps、SICAM-1参与了UAP的病理过程,奥扎格雷可逆转Ps、SICAM-1水平。

The change of p-selection and solution cell adhesion molecule-1 in patients with unstable angina pectoris and influence of ozagrel sodium

ObjectiveTo explore the change of p-selection(Ps) and solution cell adhesion molecule-1(SICAM-1) in patients with unstable angina pectoris(UAP) and influence ozagral sodium on them. MethodsThe subjects included 24 cases patients with UAP in medicine treatment. Non-medicine treatment group included 25 cases patient with UAP. Normal control groups were 22 cases. The blood was received after medicine treatment 15 days and before medicine treatment and normal control groups serum levels of Ps and SICAM-1 were measured by ELISA. ResultsThe serum levels of Ps and SICAM-1 were significantly higher in UAP group than the normal control groups serum levels of Ps and SICAM-1 were significantly lower after 15 days medicine treatment than non-medicine treatment. ConclusionPs and SICAM-1 took part in UAP pathological process. The levels of Ps and SICAM-1 could reversed by ozagral sodium. It may protect endothelium function.