| 反应停治疗难治多发性骨髓瘤的临床研究 |
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| 引用本文： | 袁朝晖,吴达军,肖希斌.反应停治疗难治多发性骨髓瘤的临床研究[J].实用临床医学(江西),2006,7(5):33-34. |
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| 作者姓名： | 袁朝晖 吴达军 肖希斌 |
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| 作者单位： | 株洲市一医院 湖南株洲412000(袁朝晖，吴达军)，中南大学湘雅医院 湖南长沙410000(肖希斌) |
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| 摘 要： | 目的:观察沙利度胺(thalidomide,反应停)治疗难治多发性骨髓瘤的疗效及副作用。方法:男性5例,女性4例,均为难治性多发性骨髓瘤,反应停治疗起始剂量为100 mg/d,根据患者耐受情况,逐渐加量,最高达400 mg/d。结果:56%(5/9)的患者对治疗有效,其中2例为完全缓解,2例部分缓解,1例进步,2例无效;患者出现不同程度的嗜睡、便秘、头晕、皮疹等副作用。结论:沙利度胺治疗难治性多发性骨髓瘤有效。
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| 关 键 词： | 多发性骨髓瘤 沙利度胺 药物治疗 |
| 文章编号： | 1009-8194(2006)05-0033-02 |
| 收稿时间： | 02 20 2006 12:00AM |
| 修稿时间： | 2006年2月20日 |
Clinical Study on Thalidomide in the Treatment of Refractory Multiple Myeloma |
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| Yuan Zhao-hui,Wu Da-jun,Xiao Xi-bin.Clinical Study on Thalidomide in the Treatment of Refractory Multiple Myeloma[J].Practical Clinical Medicine,2006,7(5):33-34. |
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| Authors: | Yuan Zhao-hui Wu Da-jun Xiao Xi-bin |
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| Institution: | 1. The First Hospital of Zhuzhou ,Zhuzhou 412000,China; 2. Xiangya Hospital of Centre-south University,Changsha 410000,China |
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| Abstract: | Objective:To investigate the efficacy and side effects of thalidomide in the treatment of refractory multiple myeloma.Methods:There were nine refractory multiple myeloma patients including five male and four female. Thalidomide was given to those patients at the starting dose of 100 mg/d and added the dose 100 mg/d each week until the maximum of 400 mg/d.Results:Among the 9 patients,two achieved completely remission,2 achieved partial remission,1 improved and 2 had no effect.The total response rate was 59%(5/9).The side effects were drowsiness,constipation,and debility.Conclusion:Thalidomide is effective in the treatment of refractory multiple myeloma. |
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| Keywords: | multiple myeloma thalidomide treatment |
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