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Relationship between antidepressants and IGF-1 system in the brain: Possible role in cognition |
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| Authors: | Nurit Grunbaum-Novak Michal Taler Irit Gil-Ad Abraham Weizman Hagit Cohen Ronit Weizman |
| Affiliation: | aLab of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel-Aviv University, Petach Tikva, Israel bMinistry of Health Mental Health Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel cBrull Community Mental Health Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel |
| Abstract: | Antidepressants facilitate neuroplasticity by stimulating trophic factors. This study evaluated the effect of fluoxetine (FLX) treatment on insulin-like growth factor-1 (IGF-1) in the rat brain and its role in the effect of FLX on cognition. IGF-1 receptor (IGF-1R) protein expression and IGF-1 mRNA levels were assessed in rat frontal cortex (FC) and hippocampus, in FLX-treated [15 mg/kg, orally; 3 (acute) or 21 (repeated) days] male Wistar rats. Rats were subjected to the Morris Water Maze test. Acute FLX administration decreased IGF-1 mRNA levels in the FC and hippocampus and increased IGF-1R levels in the FC. Repeated FLX increased both mRNA and IGF-1R levels in the FC. Repeated, but not acute, FLX treatment decreased IGF-1 mRNA in the hippocampus. FLX did not affect cognitive performance. Thus, repeated FLX treatment leads to upregulation of IGF-1 system is FC. It is possible that FLX affect FC neuroplasticity through activation of the IGF-1 system. |
| Keywords: | IGF-1 Fluoxetine Antidepressants Cognition Frontal Cortex Hippocampus |
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