Usefulness of osteoprotegerin in assessing responses to neridronate treatment in Paget's disease of bone |
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Authors: | F M Ulivieri L P Piodi G Marotta D Marchelli C Commadini L Parravicini C Verdoia P Gerundini |
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Institution: | (1) Department of Nuclear Medicine, Ospedale Maggiore, Fondazione IRCCS, Padiglione Granelli, Via F. Sforza 35, Milan, Italy;(2) Department of Gastroenterology, Ospedale Maggiore, Fondazione IRCCS, Milan, Italy;(3) Department of Orthopaedics and Traumatology, G. Pini Hospital, University of Milan, Milan, Italy |
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Abstract: | Osteoprotegerin (OPG) is a protein that inhibits of osteoclastogenesis. The aim this study was to evaluate the response of
serum OPG levels to neridronate treatment in patients with Paget's disease of bone resistant to previous therapy. Nine patients
(4 men) affected by active Paget’s disease of bone (6 polyostotic, 3 monostotic) not responsive to clodronate were studied.
Serum OPG, osteocalcin, total and bone isoenzyme of alkaline phosphatase (AP and BAP, respectively), and urinary deoxypyridinoline
(DPD) were measured before and 5 months after neridronate treatment (100 mg/day, i.v. for two days). A scintigraphic activity
index (SAI) was also calculated before treatment. Mean baseline OPG levels were within normal values and were not significantly
different 5 months after neridronate treatment. In contrast, there were significant reductions in AP (41.9%, p<0.02) and BAP (38.8%, p<0.04). Serum OPG levels correlated with DPD (r=0.925) and SAI (r=0.689). Although OPG is an important regulator of bone metabolism,
in our series of already treated patients it was not a sensitive marker for diagnosing Paget's disease and for monitoring
the response to pharmacological treatment, whereas AP and BAP confirmed their clinical usefulness. This preliminary study
requires confirmation by a study with a larger population. |
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Keywords: | Bone metabolism Neridronate Osteoprotegerin Paget's disease of bone |
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