SERUM LIPID AND APOLIPOPROTEIN A AND B LEVELS IN FAMILIAL HYPERCHOLESTEROLEMIA |
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Authors: | I H CRAIG P POULIS G HILL |
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Institution: | Senior Lecturer, Department of Medicine, University of Adelaide;Research Fellow, Department of Pediatrics, University of Adelaide;Senior Biochemist, Department of Chemical Pathology, Adelaide Childrens' Hospital |
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Abstract: | Serum lipid and apolipoprotein A (apo A) and B (apo B) levels were studied in a family with familial hypercholesterolemia (FH), which comprised two heterozygous parents, five heterozygous children, one homozygote and one normal child. Lipid levels were compared with those of age- and sex-matched normal controls. All subjects with FH had total serum cholesterol and low density lipoprotein-cholesterol (LDL-C) levels greater than the 90th percentile value for the reference range. High density lipoprotein-cholesterol (HDL-C) levels were less than the corresponding 13th percentile in heterozygous subjects. The homozygous child had grossly elevated levels of LDL-C and apo B, and very low levels of HDL-C and apo A. The most powerful discriminating variable between normal, heterozygous and homozygous family members was the LDL-C/HDL-C ratio. |
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Keywords: | Familial hypercholesterolemia serum lipoproteins serum apolipoproteins A and B serum cholesterol low density lipoprotein-cholesterol high density lipoprotein-cholesterol |
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