| 羟丙基-β-环糊精对隐丹参酮的增溶作用及其包合物的制备 |
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| 引用本文： | 罗昕,徐月红,陈宝,古练权,黄民,刘培庆. 羟丙基-β-环糊精对隐丹参酮的增溶作用及其包合物的制备[J]. 中国中药杂志, 2005, 30(17): 1328-1331 |
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| 作者姓名： | 罗昕 徐月红 陈宝 古练权 黄民 刘培庆 |
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| 作者单位： | 中山大学,药学院,广东,广州,510080 |
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| 摘 要： | 目的:制备隐丹参酮-环糊精包合物,提高隐丹参酮(CT)的溶出度。方法:绘制CT-羟丙基-β-环糊精(HPCD)相溶解度曲线,以确定包合比例;采用湿研磨法制备隐丹参酮-环糊精包合物;利用体外溶出度、差热分析、红外光谱等方法研究包合物的性质。结果:CT与HPCD的包合比例为1∶1,CT-HPCD包合物在45 min的溶出度可达到原料药的21.6倍。结论:包合物能显著提高CT的溶出度,包合物包结作用的热力学键力是CT分子的羰基与HPCD分子的羟基形成氢键。
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| 关 键 词： | 隐丹参酮 羟丙基-β-环糊精 包合物 溶出度 |
| 文章编号： | 1001-5302（2005）17-1328-04 |
| 收稿时间： | 2004-08-05 |
| 修稿时间： | 2004-08-05 |
Solubilization on cryptotanshinone by hydroxypropyl-β-cyclodextrin and preparation of their inclusion compound |
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| LUO Xin;XU Yue-hong;CHEN Bao;GU Lian-quan;HUANG Min;LIU Pei-qing. Solubilization on cryptotanshinone by hydroxypropyl-β-cyclodextrin and preparation of their inclusion compound[J]. China Journal of Chinese Materia Medica, 2005, 30(17): 1328-1331 |
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| Authors: | LUO Xin XU Yue-hong CHEN Bao GU Lian-quan HUANG Min LIU Pei-qing |
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| Affiliation: | School of Pharmaceutical Sciences, Sun Yet-sen University, Guangzhou 510080, China. |
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| Abstract: | OBJECTIVE: To prepare cryptotanshinone (CT)-cyclodextrin inclusion compound and improve dissolution of CT. METHOD: Inclusion ratio was determined by plotting the phase solubility curve of CT versus hydroxypropyl-beta-cyclodextrin (HPCD). CT-cyclodextrin inclusion compound was made by wet grinding method. Properties of the inclusion compound was investigated by in vitro dissolution test, DTA and IR spectrum. RESULT: Inclusion ratio of CT versus HPCD was 1:1. Dissolution of CT-HPCD inclusion compound at 45 min was 21.6 times of material drug. CONCLUSION: Dissolution of CT was improved remarkably in CT-HPCD inclusion compound. The complexation force of the inclusion compound was hydrogen bond formed by carbonyl group of CT and hydroxyl group of HPCD. |
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