血脂异常不同证候间载脂蛋白B/载脂蛋白A1、纤维蛋白原特点及其与证候程度的相关性研究

目的 探讨血脂异常不同证候间载脂蛋白B/载脂蛋白A1(ApoB/ApoA1)、纤维蛋白原特点及其与证候程度的关系.方法 选择2019年9月1日—2020年1月15日在辽宁中医药大学附属医院住院且符合入组标准的血脂异常患者61例,收集患者相关信息;根据中医证候辨识标准对患者进行证候的辨识,并采用中医证候量表量化证候的严重...

Study on the characteristics of apolipoproteinB/apolipoproteinA1 and fibrinogen in different syndromes of dyslipidemia and their correlation with the degree of syndromes

Objective It is to explore the characteristics of apolipoprotein B/apolipoprotein A1(ApoB/ApoAI)and fibrinogen in different syndromes of dyslipidemia and their relationship with the degree of syndrome.Methods 61 patients with dyslipidemia hospitalized in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from September 1,2019 to January 15,2020 and meet the enrollment criteria were selected,and their relevant information was collected.The syndromes of the patients were judged by the traditional Chinese medicine(TCM)syndrome identification criteria,and the severity of the syndrome was quantified by the TCM Syndrome Scale,the numbers of cases of spleen-kidney Yang deficiency syndrome and phlegm-turbid obstruction syndrome were counted,the demographic data,ApoB/ApoA1,and plasma fibrinogen levels between the two syndromes were compared,the correlation of the TCM syndrome scores of patients of the two syndromes with ApoB/ApoA1,plasma fibrinogen level were analyzed.Results Among 61 patients,there were 25 cases of spleen and kidney Yang deficiency and 36 cases of phlegm turbidity obstruction.There was no significant difference in age,respiration,heart rate,and blood pressure between patients with phlegm-turbid obstruction syndrome and spleen-kidney Yang deficiency syndrome(all P>0.05).ApoB/ApoA1 in patients with phlegm turbidity obstruction syndrome was significantly higher than that in patients with spleen and kidney Yang deficiency(P<0.05),and there was no significant difference in plasma fibrinogen levels compared with patients with spleen and kidney Yang deficiency(P>0.05).The TCM syndrome scores of dyslipidemia patients with spleen-kidney Yang deficiency were positively correlated with the levels of ApoB/ApoA1 and fibrinogen(all P<0.05).Conclusion ApoB/ApoA1 is higher in dyslipidemia patients with phlegm turbidity obstruction syndrome,which may reflect the difference and characteristics of the syndromes.ApoB/ApoA1 value and fibrinogen concentration can to some extent reflect the severity of dyslipidemia of spleen and kidney Yang deficiency.The above two characteristics are consistent with the etiology and pathogenesis analysis of TCM,which enriches the connotation of TCM syndrome differentiation.