不同剂量沙美特罗替卡松粉吸入剂对COPD患者肺功能及炎性因子的影响

目的 探讨不同剂量沙美特罗替卡松粉吸入剂对慢性阻塞性肺疾病(COPD)患者肺功能及炎性因子的影响.方法 选取2019年5月—2020年5月收治的120例COPD为研究对象,按照沙美特罗替卡松粉吸入剂给药剂量不同分为观察组与对照组,每组60例.两组均予基础治疗,同时对照组和观察组分别给予沙美特罗替卡松粉吸入剂50μg/2...

Effects of Different Doses of Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation on Lung Function and Inflammatory Factors in Patients with COPD

Objective To explore effects of different doses of Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation on lung function and inflammatory factors in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 120 patients with COPD admitted between May 2019 and May 2020 were selected as research subjects,and they were divided into observation group(n=60)and control group(n=60)according to different doses of Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation.Both groups were given basic treatments,and then control and observation groups were respectively given Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation at a dose of 50μg/250μg and 50μg/500μg simultaneously.Clinical efficacy after treatment for 6 months and occurrence of adverse reactions during the treatment were compared between two groups.Serum indexestumor necrosis factor-α(TNF-α),interleukin-8(IL-8),C-reactive protein(CRP),granulocyte-macrophage colony stimulating factor(GM-CSF),nuclear factor-κB(NF-κB),leukotriene B4(LTB4)],indicators of lung functionforced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC]and 6-min walking distance(6MWD)before and after treatment for 6 months were compared between two groups.Results The total effective rate in observation group was significantly higher than that in control group(P<0.05).After treatment,levels of FEV1,FVC,FEV1/FVC and 6MWD were significantly higher than those before treatment in two groups,and the levels in observation group were significantly higher than those in control group(P<0.05).After treatment,serum levels of TNF-α,IL-8,CRP,GM-CSF,NF-κB,and LTB4 were significantly lower than those before treatment in two groups,and the levels in observation group were significantly lower than those in control group(P<0.05).There was no significant difference in incidence rate of adverse reactions during the medication between two groups(P>0.05).Conclusion Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation may significantly improve lung function and levels of inflammatory factor in patients with COPD.When the inhaled dose is 50μg/500μg,the therapeutic effect is better without obvious adverse reactions.