长期生存继发性胶质肉瘤一例并文献复习

目的 探讨继发性胶质肉瘤的可能发病原因及诊断治疗.方法 回顾性分析1例反复行胶质瘤切除并最终发展为继发性胶质肉瘤患者的临床资料,并对相关文献进行复习.结果 患者,女,42岁,头部MRI显示左侧颞叶占位性病变;首次手术切除,术后病理诊断为间变性少突胶质细胞瘤(WHO Ⅲ级);术后第59个月发现右侧额叶占位病变,第二次手术...

Long term survival secondary gliosarcoma:a case report and literature review

Objective To investigate the possible causes,diagnosis and treatment of secondary gliosarcoma.Methods The clinical data of a patient who underwent repeated glioma resection and eventually developed into secondary gliosarcoma were analyzed retrospectively,and the relevant literature was reviewed.Results A 42 year old female patient presented with left temporal lobe space occupying on head MRI.The patient underwent the first surgical resection and was pathologically diagnosed as anaplasti coligodendroglioma(WHO gradeⅢ).59 months after operation,the right frontal lobe tumor was found and resected for the second time.The pathological diagnosis was glioblastoma(WHO gradeⅣ).Intensity modulated radiation therapy(IMRT)and temozolomide chemotherapy were performed 1 month after operation for 6 courses.31 months after the second operation,the tumor in the right frontal lobe recurred again and the third surgical resection was performed.The postoperative pathological diagnosis was gliosarcoma(WHO gradeⅣ).One month after the third operation,intensity modulated radiation therapy(IMRT)and targeted therapy with Vemurafenib was performed.The patient survived until now.Conclusion Surgery combined with chemo therapy,radiotherapy and targeted therapy may delay progression free survival in patients with gliosarcoma.