脑出血损伤相关分子模式研究进展

脑出血后产生的免疫风暴可导致神经元及其支持细胞死亡,红细胞裂解释放的血红蛋白、血红素和铁离子等细胞毒性物质也具有促进神经细胞死亡的作用。神经细胞死亡后释放的损伤相关分子模式(DAMP)激活固有免疫反应,导致炎症反应-细胞死亡-DAMP释放-炎症反应的恶性循环,是脑出血后继发性脑损伤的重要机制。本文旨在对目前开展的一系列探讨DAMP在脑出血继发性脑损伤中作用的研究进展进行概述,以为进一步的基础研究与临床转化研究提供参考。

Research progress on damage-associated molecular patterns in intracerebral hemorrhage

After the onset of intracerebral hemorrhage(ICH), the immune storm causes the massive death of neurons and their supporting cells. Cytotoxic substances such as hemoglobin, heme and iron ions released by red blood cells lysis also promote death of neurons. After neurons died, damage-associated molecular patterns(DAMP) are released to activate the innate immune response, leading to a vicious circle of "inflammatory response-cell death-DAMP release-inflammatory response", which is an important mechanism of secondary brain injury after ICH. A series of studies have explored the role of DAMP in secondary brain injury after ICH. This review summarizes the research progress and provides references for further basic research and clinical translational research.