| 丹栀逍遥散加减治疗胃食管反流病肝胃郁热证的临床疗效及对患者血清炎性因子的影响 |
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| 引用本文： | 税典奎,罗诗雨,陈峭,叶剑,蒋应玲,梁谊深,宁庆云,覃凌娜.丹栀逍遥散加减治疗胃食管反流病肝胃郁热证的临床疗效及对患者血清炎性因子的影响[J].河南中医,2019(7):1045-1048. |
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| 作者姓名： | 税典奎 罗诗雨 陈峭 叶剑 蒋应玲 梁谊深 宁庆云 覃凌娜 |
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| 作者单位： | 柳州市中医医院;广西中医药大学 |
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| 基金项目： | 国家自然科学基金项目(81403383);广西重点研发项目(桂科AB16380206) |
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| 摘 要： | 目的:探讨丹栀逍遥散加减治疗胃食管反流病(gastroesophageal reflux disease,GERD)肝胃郁热证的临床疗效及对患者炎性因子的影响。方法:选取柳州市中医医院脾胃病科2017年6月至2018年7月住院治疗的GERD肝胃郁热证患者80例,按照随机数字表法分为治疗组和对照组各40例。对照组给予兰索拉唑胶囊、枸橼酸莫沙必利胶囊治疗,治疗组在对照组治疗的基础上加用丹栀逍遥散加减治疗。观察两组患者治疗前后主要临床症状积分,血清胃动素(motilin,MTL),胃蛋白酶原(pepsinogen,PG),超氧化物歧化酶(serum superoxide dismutase,SOD)和脂质过氧化物(lipid peroxide,LPO)的水平。结果:对照组有效率为78. 38%,治疗组有效率为94. 74%,治疗组有效率高于对照组,差异有统计学意义(χ2=5. 192,P <0. 05);治疗组治疗后烧心、反酸、胸痛、反胃积分均明显低于对照组,差异有统计学意义(P <0. 05);治疗组治疗后血清MTL、PG、SOD和LPO水平低于对照组,差异有统计学意义(P <0. 05)。结论:丹栀逍遥散加减治疗GERD肝胃郁热证疗效佳,在改善患者主要临床症状方面优于西药,能降低患者血清MTL、PG、SOD和LPO水平,减轻胃、食管黏膜炎症反应和氧化应激反应。
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| 关 键 词： | 胃食管反流病 肝胃郁热证 丹栀逍遥散加减 胃蛋白酶原 超氧化物歧化酶 |
The Clinical Efficacy of Modified Free Wanderer Powder of Cortex Moutan and Fructus Gardeniae Fruit on Gastroesophageal Reflux Disease with Liver-Stomach Stagnation-Heat Syndrome and its Influence on Serum Inflammatory Factors |
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| SHUI Dian-kui,LUO Shi-yu,CHEN Qiao,YE Jian,JIANG Ying-ling,LIANG Yi-shen,NING Qing-yun,QIN Ling-na.The Clinical Efficacy of Modified Free Wanderer Powder of Cortex Moutan and Fructus Gardeniae Fruit on Gastroesophageal Reflux Disease with Liver-Stomach Stagnation-Heat Syndrome and its Influence on Serum Inflammatory Factors[J].Henan Traditional Chinese Medicine,2019(7):1045-1048. |
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| Authors: | SHUI Dian-kui LUO Shi-yu CHEN Qiao YE Jian JIANG Ying-ling LIANG Yi-shen NING Qing-yun QIN Ling-na |
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| Institution: | (Liuzhou Hospital of TCM ,Liuzhou,Guangxi,China,545001;Guangxi University of TCM ,Nanning,Guangxi,China,530001) |
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| Abstract: | SHUI Dian-kui;LUO Shi-yu;CHEN Qiao;YE Jian;JIANG Ying-ling;LIANG Yi-shen;NING Qing-yun;QIN Ling-na(Liuzhou Hospital of TCM ,Liuzhou,Guangxi,China,545001;Guangxi University of TCM ,Nanning,Guangxi,China,530001) |
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| Keywords: | gastroesophageal reflux disease(GERD) liver-stomach stagnation-heat syndrome Modified Free Wanderer Powder of Cortex Moutan and Fructus Gardeniae Fruit pepsinogen superoxide dismutase |
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