| 硝酸布康唑的合成 |
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| 引用本文： | 张海波,金荣庆,王志贤.硝酸布康唑的合成[J].海峡药学,2009,21(12):215-217. |
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| 作者姓名： | 张海波 金荣庆 王志贤 |
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| 作者单位： | 扬子江药业集团有限公司,江苏(泰州)新药研究院,泰州,225321 |
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| 摘 要： | 目的合成硝酸布康唑。方法以4-氯苄基氯为起始原料,经Grignard反应、缩合、氯化、缩合、成盐等5步反应制得目标化合物。结果目标化合物的熔点、红外光谱均与文献报道一致,总收率为37.9%,纯度为99.6%（HPLC法）。结论本工艺操作简单,成本较低,适合工业化生产。
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| 关 键 词： | 硝酸布康唑 抗真菌 合成 |
Synthesis of butoconazole nitrate |
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| ZHANG Hai-bo,JIN Rong-qing,WANG Zhi-xian.Synthesis of butoconazole nitrate[J].Strait Pharmaceutical Journal,2009,21(12):215-217. |
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| Authors: | ZHANG Hai-bo JIN Rong-qing WANG Zhi-xian |
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| Institution: | (Yangtze River Pharmaceutical Group, Jiangsu (Taizhou) New Medicine Research Institution, Taizhou 225321, China) |
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| Abstract: | OBJECTIVE To synthesize butoconazole nitrate.METHODS The Target compound was synthesized from α,4-dichlorotoluene as a starting material via five steps including Grignard reaction,condensation,chlorination,condensation and salification.RESULTS The structure of the target compound was confirmer by melting point,IR analysis.The total yield of butoconazole nitrate was 37.9%,HPLC purity 99.6%.CONCLUSION This cost-saving and simplified method can be used in the industrial manufacture. |
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| Keywords: | Butoconazole nitrate Antifungal agents Synthesis |
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