Basic fibroblast growth factor treatment for skin ulcerations in scleroderma |
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| Authors: | Yamanaka Kei-ichi Inaba Tomoko Nomura Eriko Hurwitz Daniel Jones David A Hakamada Arata Isoda Kenichi Kupper Thomas S Mizutani Hitoshi |
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| Affiliation: | Department of Dermatology, Mie University, Graduate School of Medicine, Japan. yamake@clin.medic.mie-u.ac.jp |
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| Abstract: | We report the use of topical application of recombinant human basic fibroblast growth factor (rhbFGF) to successfully treat therapy-resistant, chronic leg ulcers in scleroderma. Endothelial cell FGF receptors are directly stimulated by bFGF; also, bFGF promotes the regeneration of capillary-rich granulation tissue. We conclude that topical bFGF may be a powerful new pharmacologic tool for treating severe skin ulcers. |
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