| 不同程度猴脑缺血模型的CT灌注和脑血管造影评价 |
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| 引用本文： | 周智鹏,邓燕贤,邱维加,庾俊雄,冯飞玲. 不同程度猴脑缺血模型的CT灌注和脑血管造影评价[J]. 临床放射学杂志, 2008, 27(11): 1585-1588 |
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| 作者姓名： | 周智鹏 邓燕贤 邱维加 庾俊雄 冯飞玲 |
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| 作者单位： | 桂林医学院附属医院放射科,541001;桂林医学院附属医院麻醉科,541001;桂林医学院病理生理教研室,541001 |
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| 摘 要： | 目的 探讨不同程度脑缺血模型的建立以及栓塞剂量对猴自体血栓栓塞脑缺血模型的影响.材料与方法成年食蟹猴20只,随机分成5组:对照组、轻度缺血组、中度缺血组、重度缺血组和极重度缺血组,每组各4只.各组动物经介入法插管至大脑中动脉,对照组注入一定量的盐水,其他各组注入不同体积的自体血栓造成大脑中动脉血栓栓塞,介入血管造影( DSA )和CT灌注(CTP)扫描证明栓塞成功,分别于术后30 min和120 min行CTP扫描,测量脑血流平均通过时间(MTT)值,术后14天连续观察行为学表现.结果 术后30 min MTT:所有手术组MTT测量值明显高于对照组并且有显著差别;术后120 min MTT:轻度缺血组和对照组未见明显差别,其他各组和对照组可见明显差别;术后死亡率:极重度组和重度组明显高于其他组,极重度组又明显高于重度组;术后行为学表现:重度组、中度组和轻度组可见明显行为学改变.各组有明显差异的数据均有统计学意义.结论 猴不同程度脑缺血模型的建立,对研究脑缺血疾病有重要的作用;DSA和CTP对早期脑缺血疾病的诊断和预后判断有重要的价值.
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| 关 键 词： | 猴 脑缺血模型 CT灌注扫描 血管造影 |
The DSA and CT Perfusion Evaluation of New Model of Artery Occlusion in Monkey |
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| ZHOU Zhipeng,DENG Yanxian,QIU Weijia,et al.. The DSA and CT Perfusion Evaluation of New Model of Artery Occlusion in Monkey[J]. Journal of Clinical Radiology, 2008, 27(11): 1585-1588 |
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| Authors: | ZHOU Zhipeng DENG Yanxian QIU Weijia et al. |
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| Affiliation: | ZHOU Zhipeng,DENG Yanxian,QIU Weijia,et al.Department of Radiology,Affiliated Hospital of Guilin Medical College 541001,P.R.China |
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| Abstract: | Objective To investigate the role of DSA and CT perfusion (CTP) scanning in monkey middle cerebral artery occlusion (MCAo) model, which were established by various doses of fibrin embolus injected into the middle cerebral artery(MCA). Materials and Methods 20 monkeys were randomly assigned to 5 groups including control, mild ischemia, moderate ischemia, serious and very serious ischemia groups.The various doses of embolus lodge were injected from the segment M1 of MCA in monkey and characterized their effec... |
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| Keywords: | Monkey Ischemic model CTP DSA |
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