| 脾切除对小鼠腹腔巨噬细胞数量和功能的影响 |
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| 引用本文： | 陈增良 杨泽然. 脾切除对小鼠腹腔巨噬细胞数量和功能的影响[J]. 浙江大学学报(医学版), 1999, 28(4): 148-149,153 |
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| 作者姓名： | 陈增良 杨泽然 |
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| 作者单位： | 浙江大学医学院!浙江杭州310031 |
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| 摘 要： | 目的：研究脾切除对小鼠腹腔巨噬细胞数量和功能活性的影响。方法：术后4周获取腹腔常居巨噬细胞和炎症巨噬细胞，检测其数量、吞噬功能和一氧化氨水平。结果：与正常对照组和假手术组比较，脾切除组小鼠的2种巨噬细胞不仅数量明显减少，而且它们的吞噬功能和一氧化氮水平呈明显下降。结论：提示脾切除造成的单核吞噬细胞继发性炎症反应的捐伤和巨噬细胞功能活性的降低，可能是脾切除后(凶险性)感染的重要因素。
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| 关 键 词： | 巨噬细胞，腹膜／病理生理学 脾切除术 小鼠 |
Effect of Splenectomy on the Number and Function of Peritoneal Macrophages in Mice |
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| CHEN Zeng liang,YANG Ze ran. Effect of Splenectomy on the Number and Function of Peritoneal Macrophages in Mice[J]. Journal of Zhejiang University. Medical sciences, 1999, 28(4): 148-149,153 |
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| Authors: | CHEN Zeng liang YANG Ze ran |
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| Abstract: | Objective:To observe the effect of splenectomy on the number and function of peritoneal macrophages in mice.Methods:Peritoneal resident macrophages (PRM) and peritoneal inflammatory macrophages (PIM) were harvested 4 weeks after surgery;their number and functions were measured.Results:There was a significant reduction in the number of PRM or PIM in the splenectomy group.Phagocytosis and nitric oxide (NO) level were decreased markedly in the splenectomy group compared with sham operated and control mice.Conclusion:These findings suggest that splenectomy probably play a role in the pathogenesis of postsplenectomy bacterial infection by the impairment in a secondary inflammatory reaction of mononuclear phagocytes and macrophage activity. |
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| Keywords: | Macrophages peritoneal/physiopathol Splenectomy Mice |
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