恩丹西酮预防经皮肾穿刺取石患者寒战效果观察

目的观察椎管内麻醉时静脉给予恩丹西酮对经皮肾穿刺取石(PCNL)患者寒战的预防效果。方法在腰麻-硬膜外联合阻滞下行PCNL患者90例,ASAⅠ~Ⅱ级,随机分成恩丹西酮组、曲马多组和对照组,每组30例,麻醉前开放静脉通路,恩丹西酮组给予恩丹西酮8 mg,曲马多组给予曲马多50 mg,对照组给予盐水10 m l,观察记录患者术中寒战发生的情况,并持续监测呼吸、循环变化。结果恩丹西酮组(10%)和曲马多组(6.67%)寒战发生率明显低于对照组(46.67%,P<0.05),3组围手术期呼吸循环变化比较无显著性差异(P>0.05);恩丹西酮组(3.33%)术中恶心、呕吐的发生率明显低于对照组(23.33%)和曲马多组(26.67%,P<0.05),而曲马多组与对照组比较无显著性差异(P>0.05)。结论麻醉前预先静脉注射恩丹西酮可以预防PCNL患者寒战的发生,并可降低术中恶心、呕吐的发生率。

Preventive effect of ondansetron on shivering in percutaneous nephrolithotomy

Objective To observe the preventive effects of ondansetron in percutaneous nephrolithotomy(PCNL) after intraspinal anesthesia.Methods Ninety ASAⅠ～Ⅱ patients undergoing PCNL were randomly divided into ondansetron group,tramadol group and control group,30 cases in each group.Ondansetron group was given 8 mg of ondansetron,tramadol group was given 50 mg of tramadol,and control group was given 10 ml of saline.Observed and recorded the rate of shivering was during operation,and blood pressure and respiration were measured.Results The rate of shivering in ondansetron group(10%)and tramadol group(6.67%) were signicantly lower than that in control group(46.67%,P<0.05).The difference of blood pressure and respiration was not signifiant in three groups(P>0.05);The rate of nausea and vomit in ondansetron group(3.33%) were signicantly lower than control group(23.33%) and tramadol group(26.67%,P<0.05),but the difference was not significant between control group and tramadol group(P>0.05).Conclusion Intraveneous injection ondansetron 8mg before anaesthesia can prevent shivering in PCNL,and ondansetron can reduce the rate of nausea and vomit.