2型糖尿病患者血清胆红素与颈动脉内膜中层厚度的关系

目的 探讨2型糖尿病(T2DM)患者血清胆红素水平与颈动脉内膜中层厚度(CIMT)的关系.方法 将72例T2DM患者依据CIMT值,分为内膜正常组(35例)、动脉硬化组(37例),记录患者的年龄、性别、糖尿病病程、吸烟史、体质量指数(BMI)、血压、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、血脂、血清胆红素水平,并进行统计学分析.结果 动脉硬化组年龄(60.03±9.68)岁、糖尿病病程(7.81±5.63)年,显著高于内膜正常组年龄(52.29±7.46)岁、糖尿病病程(4.47±3.95)年,而动脉硬化组总胆红素(TBIL)、间接胆红素(IBIL)分别为(11.96±4.73)μmol·L-1、(8.86±3.61)μmol·L-1,低于内膜正常组的(14.05±3.98)μmol·L-1、(10.54±3.17)μmol·L-1,均差异有统计学意义(P<0.05).血清胆红素水平与CIMT呈负相关(P<0.05).结论 T2DM患者的胆红素水平变化与颈动脉内膜中层厚度密切相关.

Association of serum bilirubin level and carotid intima-media thickness in type 2 diabetes mellitus

Objective To explore the relationship between serum bilirubin level and carotid intima -media thickness (CIMT) in type 2 diabetes mellitus patients.Methods Seventy-two patients with T2DM were assigned into the normal group (35 cases) and athero-sclerotic group (37 cases) according to the value of CIMT.Patients'age,gender,course of diabetes,smoking history,body mass in-dex (BMI),blood pressure,fasting plasma glucose (FBG),HbA1c,lipid profiles and serum bilirubin were measured and analyzed . Results In the atherosclerotic group,patients'age was (60.03 ±9.68) years old and duration of diabetes was (7.81 ±5.63) years,which were significantly higher than those in the normal group (52.29 ±7.46) years old and diabetes duration of (4.47 ± 3.95) years.Total bilirubin (TBIL) and indirect bilirubin (IBIL) were (11.96 ±4.73) μmol· L-1 and (8.86 ±3.61) μmol· L -1 in the atherosclerotic group,which were lower than those in the normal group,(14.05 ±3.98) μmol· L -1 and (10.54 ±3.17)μmol· L-1 .There were significant differences (P <0.05).Serum bilirubin level was negatively associated with carotid intima-media thickness (P <0.05).Conclusions The change of serum bilirubin level in patients with T2DM is closely related to the carotid inti-ma-media thickness.