牙周炎合并AECOPD患者血清IL-6、IL-8水平及相关性研究

目的 探讨慢性牙周炎及慢性阻塞性肺疾病急性加重(AECOPD)患者的牙周状况、肺功能状况和血清IL-6、IL-8的水平及两种疾病可能存在的相互关系.方法 选取32例符合条件的慢性牙周炎合并AECOPD的患者记为AECOPD+P组;32例健康人记为H组,32例符合条件的单纯慢性牙周炎患者记为P组;32 例符合条件的单纯AECOPD的患者记为AECOPD组.采集所有研究对象的临床指标并使用ELISA法检测各组研究对象血清中白细胞介素6(IL-6)与白细胞介素8 ( IL-8)含量.结果 AECOPD +P 组附着水平(AL)明显低于P组(P＜0.000 1);AECOPD+P组肺功能指标明显低于AECOPD组(P＜0.05);AECOPD+P组较H组、P组、AECOPD组的血清IL-6 与IL-8 水平均明显升高( P＜0.000 1);P组和AECOPD组较H组的血清IL-6 与IL-8 水平均明显升高(P＜0.000 1).结论 IL-6和IL-8可能与慢性牙周炎和慢性阻塞性肺疾病的病理机制有关,两种疾病可能互相影响,加重各自发生发展的过程.

Clinical significance of IL-6 and IL-8 in patients with periodontal disease and AECOPD and their correlations

Objective To investigate the serum levels of IL-6 and IL-8 in patients with chronic periodontal disease and acute exacerbation of chronic obstructive pulmonary disease( AECOPD) and the possible relationship between the two diseases. Methods 32 eligible patients with chronic periodontitis and AECOPD were enrolled as AECOPD+ P group; 32 healthy individuals were enrolled as H group and 32 eligible patients with chronic periodontitis as P group; 32 patients were eligible patients in the AECOPD condition were recorded as AECOPD. ELISA assay was used to detect the serum levels of IL-6 and IL-8 in the four groups. Results The attachment level was significantly different between group AECOPD+P and group P( P＜0.000 1) . The pulmonary function indexes including VC MAX% pre index, FEV1% pre index, FEV1/FVC( % ) index were significantly different between group AECOPD+P and group AECOPD(P＜0.05). In group AECOPD+P the IL-6 and IL-8 levels were significantly higher than that in group H, P, and AECOPD(P＜0.000 1). In group P and AECOPD the IL-6 and IL-8 levels were signifi-cantly higher than that in group H(P＜0.000 1). Conclusion IL-6 and IL-8 may be associated with the patho-genesis of periodontal disease and AECOPD closely, periodontal disease and AECOPD may affect and aggravate the development process each other.