| p38信号通路在三叉神经痛ION-CCI模型大鼠中的研究 |
| |
| 引用本文： | 刘雨,崔曼曼,张越,施秀芳,温泽惠,王烈成,王元银. p38信号通路在三叉神经痛ION-CCI模型大鼠中的研究[J]. 安徽医科大学学报, 2018, 53(6): 894-897. DOI: 10.19405/j.cnki.issn1000-1492.2018.06.014 |
| |
| 作者姓名： | 刘雨 崔曼曼 张越 施秀芳 温泽惠 王烈成 王元银 |
| |
| 作者单位： | 安徽医科大学口腔医学院,合肥,230032;安徽医科大学基础医学院生理学教研室,合肥,230032 |
| |
| 基金项目： | 国家自然科学基金(81271162),安徽省2014年科技攻关计划项目(1401045013),合肥市自主创新政策"借转补"资金立项项目(YW201608080001) |
| |
| 摘 要： | 目的 检测三叉神经痛( TN)模型大鼠三叉神经节(TG)内p-p38蛋白表达量的变化.方法 采用眶下神经缩窄术(ION-CCI)制备大鼠三叉神经痛模型,将雄性SD大鼠随机分为两组,即对照组( sham 组)和眶下神经缩窄术组(ION-CCI组). Frey毛刷测定大鼠触须垫机械痛阈,West-ern blot检测p-p38的表达量.结果 ION-CCI组大鼠机械痛阈明显低于 sham组(n=5,P ＜0.01). ION-CCI 组大鼠TG内p-p38 的蛋白表达量均明显高于建模前正常大鼠( n=3,P＜0.05).结论 p38信号通路可能与TN的发生发展密切相关.
|
| 关 键 词： | 三叉神经痛 三叉神经节 眶下神经缩窄术 |
Role of p38 signaling pathway in the trigeminal neuralgia of ION-CCI model in rats |
| |
| Abstract: | Objective To detect the expression of p-p38 proteins in intrigeminal ganglions( TG) of trigeminal neu-ralgia ( TN) model in rats. Methods The TN model of rat was established by chronic constriction injury of the in-fraorbital never ( ION-CCI) . Male SD rats were randomly diviede into 2 groups: control group ( sham group) and ION-CCI group. The mechanical withdrawal thresholds of vibrissa pad in two groups of rats were measured by von Frey hairs. The proteins of p-p38 in TG were detected by Western blot test. Results The mechanical thresholds of ION-CCI group were obviously lower than that in sham group (n=5,P＜0.01). The p-p38 proteins in TG of ION-CCI group was over-expressed obviously after operation, which was significant different compared with that before operation ( n=3, P＜0.05) . Conclusion p38 signaling pathway may be closely related to the development of TN. |
| |
| Keywords: | |
| 本文献已被 万方数据 等数据库收录！ |
|
