儿童青少年首发精神分裂症认知障碍特征

目的 探讨儿童青少年首发精神分裂症患者认知功能损害特征.方法 对30例儿童青少年首发精神分裂症患者(首发组)和30例随机选取的健康志愿者(健康组)的认知功能进行研究.所有参与测试者受教育年限≥6年,对两组人员都进行精神分裂症认知功能成套测试共识版( MC-CB)测试,分析儿童青少年首发精神分裂症患者认知功能的特点和损害特征.患者的临床症状采用阳性与阴性症状量表(PANSS)进行评估.结果 除情绪管理测验得分两组没有差异外,其余各测试得分和MCCB总分差异统计学意义(P＜0. 05);首发患者的MCCB总分、持续性操作测验得分与PANSS量表中阴性症状因子分相关(P＜0. 05),而连线测验得分与患者PANSS量表中阳性症状因子分存在一定相关性.结论 儿童青少年首发精神分裂症患者的认知功能存在明显损害;首发精神分裂症患者的认知功能受损与阴性症状相关.

Cognitive impairment in adolescents with first-episode schizophrenia

Objective To explore the impairment of cognitive function in adolescents with first-episode schizophre-nia. Methods The study was to investigate the cognitive function of 30 adolescents with first episode schizophrenia (first episode schizophrenia group) and 30 randomly selected healthy volunteers (normal population group). All participants were more than 6 years of schooling and completed MATRICS consensus cognitive battery ( MCCB) test. The characteristics and impairment of cognitive function in adolescents with first-episode schizophrenia were analyzed. The patients'clinical symptoms were assessed by the positive and negative symptom scale ( PANSS) . Re-sults In addition to the scores of emotional management subtest were no difference between the two groups, the scores of the rest subtests and total score of MCCB test were significant difference ( P＜0. 05) . The total scores of MCCB test and the scores of continuous performance test-identical pair in the first episode patients was correlated with the negative symptom factor scores in the PANSS scale ( P＜0. 05) , while there was a certain correlation be-tween the scores of trail making test and the positive symptom factor scores in the PANSS scale. Conclusion The cognitive function in adolescents with first-episode schizophrenia is significantly impaired. The cognitive impairment is associated with negative symptoms in first-episode schizophrenia.