趋化因子及其受体在肿瘤发生发展中作用的研究进展

趋化因子家族通过作用于跨G蛋白偶联受体来介导趋化因子的活性.趋化因子及其受体形成同源或异源二聚体的能力以及趋化因子与趋化因子受体之间的相互作用,使得趋化因子蛋白家族在很多方面具有目前尚未完全了解的可塑性及复杂性.趋化因子既是炎性反应中的必需调节剂又可以介导宿主对肿瘤的反应.大量数据表明,趋化因子及其受体影响大多数肿瘤的形成.因此,笔者将从趋化因子及其受体的信号转导开始,对其如何影响肿瘤细胞的增殖、凋亡、自噬及免疫浸润作一综述.

Research progress on the role of chemokines and chemokine receptor in the development of tumor

The chemokine family mediates the activity of chemokines by acting on G protein -coupled receptors.Because chemokines and their receptors have the ability to form homologous or heterodimers and the interaction between chemokines and chemokine receptors ,the chemokine family has many aspects that are not yet fully understood such as plasticity and complexity .Chemokines not only are essential regulators in the inflammatory response but also mediate the host 's response to tumor.Many studies have found that chemokines and their receptors affect the formation of most tumors .Therefore,this article will begin with the signal transduction of chemokines and their receptors,and summarize how they affect the proliferation ,apoptosis,autophagy and immune infiltration of tumor cells .