乙醛脱氢酶2基因多态性与冠心病严重程度的相关性研究

目的 探讨中国北方汉族人群中,乙醛脱氢酶2 (AL-DH2)基因多态性与冠心病严重程度之间的关系.方法 本研究共纳入505例患者,包括375例冠心病患者及明确排除的130例非冠心病患者,通过Sanger测序法对ALDH2基因的多态性进行分析,比较冠心病组与非冠心病组间ALDH2基因型的分布;同时,将以上患者分为非冠心病组、单支病变组、多支病变组,比较三组之间ALDH2各基因型别的分布;并对野生型和突变型的所有病变血管进行Gensini评分,比较Gensini评分有无差异.结果 ALDH2基因型的分布在冠心病和非冠心病组中,差异无统计学意义;在不同病变支数之间的ALDH2基因型分布以及野生型、突变型两组的 Gensini评分,均差异无统计学意义.结论 ALDH2基因多态性与中国北方汉族人群冠心病严重程度之间无明显相关性.

Association of aldehyde dehydrogenase 2 gene polymorphism with severity of coronary heart disease

Objective To investigate the relationship between aldehyde dehydrogenase 2 (ALDH2) gene polymorphism and severity of coronary heart disease in Chinese Han population in northern China. Methods A total of 505 patients were included in the study, including 375 patients with coronary heart disease and 130 patients with non-coronary heart disease. The ALDH2 gene polymorphism was analyzed by Sanger sequencing. Compared the distribution of ALDH2 genotype between coronary heart disease group and non-coronary heart disease group. At the same time, the above patients were divided into non-coronary heart disease group, single-vessel disease group, multi-vessel disease group. Gensini scores were compared for all vascular lesions of wild type and mutant type, to compare the distribution of ALDH2 genotypes among the three groups and the Gensini score between wild type and mutant type. Results There was no significant difference in the distribution of ALDH2 genotype between coronary heart disease and non-coronary heart disease group. There was no significant difference in the distribution of AL-DH2 genotype among different vessels and in Gensini score between wild type and mutant group. Conclusion There is no significant correlation between ALDH2 gene polymorphism and the severity of coronary heart disease in Chinese Han population in northern China.