果糖二磷酸钠对脑出血患者的心肌酶谱的影响

目的 探讨脑出血患者应用果糖二磷酸钠(FDP)对心肌酶谱的影响.方法 选取脑出血患者64例,根据是否应用FDP分为对照组和治疗组,各32例,两组均给予常规治疗.其中治疗组在常规治疗的基础上给予果糖二磷酸钠(用法用量:5.0克/次,静脉滴注,2次/天,疗程7天),比较入院时第1天、第3天、第7天心肌酶谱乳酸脱氢酶(LDH)、磷酸肌酸激酶(CK)、门冬氨酸氨基转移酶(AST)及磷酸肌酸激酶同工酶(CKMB)水平.结果 心肌酶AST、LDH、CK及CKMB入院第3天治疗组的检测结果为:(46.41±27.53)IU·L-1、(285.94±42.84)IU·L-1、(352.81±148.69)IU·L-1、(37.47±12.05)IU·L-1;心肌酶AST、LDH、CK及CKMB入院第7天治疗组的检测结果为:(35.59±13.44)IU·L-1、(249.28±50.37)IU·L-1、(260.81±98.12)IU·L-1、(23.13±8.35)IU·L-1.入院第1天AST、LDH、CK及CKMB治疗组与对照组差异无统计学意义(P分别为0.504、0.935、0.672、0.588),第3、7天对照组AST、LDH、CK及CKMB均较治疗组升高,差异有统计学意义(第3天P分别为0.003、0.001、0.025、0.009;第7天P值分别为:0.001、0.013、0.013、0.001).治疗组和对照组的AST、LDH、CK及CKMB第3天均较第1天时升高,差异有统计学意义(P<0.01),治疗组AST、LDH、CK及CKMB第7天与第1天相比较差异无统计学意义(P>0.05),对照组AST、LDH、CK、及CKMB第7天高于第1天,差异有统计学意义(P<0.01).结论 果糖二磷酸钠应用于脑出血患者可以降低急性期心肌酶谱,对心脏有保护作用.

Effect of fructose sodium diphosphate on myocardium enzymogram in patients with cerebral hemorrhage

Objective To discuss the effect of fructose sodium diphosphate (FDP) on myocardium enzymogram in patients with cere -bral hemorrhage.Methods Select 64 cases of cerebral hemorrhage patients ,were randomly divided into control group and treatment group , In the two groups were given conventional treatment .The treatment group given fructose sodium diphosphate ( Usage : 5 .0 g ,intravenous drip,bid,treatment course:7 day).Comparison on the first /third /seventh day of Myocardium enzymogram level :AST, LDH,CK,CKMB.Results The myocardium enzymogram AST、LDH、CK、and CKMB test results of treatment group in the thrid day :(46.41 ±27.53) IU· L-1、(285.94 ±42.84) IU· L-1、(352.81 ±148.69) IU· L-1、(37.47 ±12.05) IU· L-1;The myocardium enzymogram(AST、LDH、CK、and CKMB)test results of treatment group in the seventh day :(35.59 ±13.44) IU· L-1、(249.28 ± 50.37) IU· L-1、(260.81 ±98.12) IU· L-1、(23.13 ±8.35) IU· L-1 .There was no significant difference in the AST ,LDH,CK, and CKMB on the first day of admission between control group and treatment group (P =0.504,0.935,0.672,0.588,respectively). The levels of AST,LDH,CK,and CKMB were significantly higher in the control group than those in the treatment group on the third and seventh day (P =0.003,0.001,0.025,0.009) vs (P =0.001,0.013,0.013,0.001)].The levels of AST,LDH,CK,and CKMB of the control group and the treatment group on the third day were higher than those on the first day (P <0.01).There was no significant difference in the levels of AST,LDH,CK,and CKMBs in the treatment group between the first day and seventh day of admission (P >0.05).The levels of AST,LDH,CK,and CKMB in the control group on the seventh day of admission were higher than those on the first day;the difference had statistically significance (P <0.01).Conclusions The application of fructose sodium diphosphate in patients with cerebral hemorrhage can reduce the acute myocardium enzymogram and protect the heart .