| Comparison of serum cardiac troponin-Ⅰ and creatine kinase MB isoenzyme concentrations in asphyxiated neonates |
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| 摘 要： | Objective： To assess the correlation of signs of myocardial damage to serum cardiac troponin I （cTnI） and creafine kinase MB isoenzyme （CK-MB） concentrations. Methods： Blood samples were collected from 25 term asphyxiated neonates and 25 controls at 12 h of age by immunoassay. The asphyxiated neonates were followed up until discharge or death. Results： Asphyxiated neonates had significantly higher concentrations of cTnI and CK-MB than controls （ P 〈 0.001 ）. Serum cTnI concentrations were significantly higher in asphyxiated neonates who developed hypotension, heart failure or those had low ejection fraction （P 〈 0.01 ）. Serum cTnI concentrations were significantly higher in asphyxiated who died than those who survived （P 〈 0. 01）. There was no significant difference in serum CK-MB mass concentrations between asphyxiated neonates with and without these complications. Conclusion： Unlike CK-MB, serum cTnI concentrations are significantly higher in asphyxiated neonates who died or developed cardiac dysfunction.
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| 关 键 词： | 肌钙蛋白 肌酸激酶 围产期 心脏水肿 |
Comparison of serum cardiac troponin-I and creatine kinase MB isoenzyme concentrations in asphyxiated neonates |
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| Nouran F. Hussien Eman A. Abdel Ghany Amany E.Elwan Yasser H.Kamel Dina K.Ali. Comparison of serum cardiac troponin-I and creatine kinase MB isoenzyme concentrations in asphyxiated neonates[J]. Journal of Hainan Medical College, 2009, 15(1): 31-36 |
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| Authors: | Nouran F. Hussien Eman A. Abdel Ghany Amany E.Elwan Yasser H.Kamel Dina K.Ali |
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| Affiliation: | Pediatric Department, Neonatology Department, Cairo University Hospitals |
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| Abstract: | Objective:To assess the correlation of signs of myocardial damage to serum cardiac troponin I(cTnI)and creatine kinase MB isoenzyme(CK-MB)concentrations.Methods:Blood samples were collected from 25 term asphyxiated neonates and 25 controls at 12 h of age by immunoassay.The asphyxiated neonates were followed up until discharge or death.Results:Asphyxiated neonates had significantly higher concentrations of cTnI and CK-MB than controls(P<0.001).Serum cTnI concentrations were significantly higher in asphyxiated neonates who developed hypotension,heart failure or those had low ejection fraction(P<0.01).Serum cTnI concentrations were significantly higher in asphyxiated who died than those who survived(P<0.01).There was no significant difference in serum CK-MB mass concentrations between asphyxiated neonates with and without these complications.Conclusion:Unlike CK-MB,serum cTnI concentrations are significantly higher in asphyxiated neonates who died or developed cardiac dysfunction. |
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| Keywords: | Cardiac troponin Ⅰ Creatine kinase MB isoenzyme(CK-MB) Perinatal asphyxia Cardiac dysfunction |
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