上海地区育龄期妇女,孕妇及其新生儿巨细胞病毒感染的调查

INVESTIGATION OF HUMAN CYTOMEGALOVIRUS INFECTION OF CHILDBEARING AGE WOMEN, PREGNANT WOMEN AND THEIR INFANTS

In order to investigate the situation of human cytomegalovirus (HCMV) infection in Shanghai, we have detected the HCMV specific antibody in 1048 serum samples of child- bearing age women and 289 paired serum samples of mother and infant by indirect ELISA. The positive rate of HCMV-IgG of childbearing age women was 93.5%. The positive rates of HCMV-IgG in<18, 20-29 and 30-45 years of age were 54.9%, 89.7% and 95.5% respectively. It suggests that the HCMV infection increases with age. In addition, we also found that HCMV infection is related to the status of socioeconomy and marriage. Two hundred seventy-three maternal serum samples and 266 umbilical cord serum samples were positive for HCMV-IgG, with positive rates of 94.46% and 92.04% respectively. While 13 maternal serum samples and 10 umbilical cord serum samples were positive for HCMV-IgM, with positive rates of 4.49% and 3.46% respectively. The close relation of HCMV-IgM levels between mothers and their babies indicated that infants might acquire congenital infection from their mothers with positive HCMV-IgM.