| 美洛昔康贴片抗炎作用实验研究 |
| |
| 引用本文： | 王彩霞,张宏武,王荣端,刘玉兰.美洛昔康贴片抗炎作用实验研究[J].实用药物与临床,2006,9(1):19-22. |
| |
| 作者姓名： | 王彩霞 张宏武 王荣端 刘玉兰 |
| |
| 作者单位： | 1. 石药集团中奇制药技术(石家庄)有限公司,石家庄,050051
2. 沈阳药科大学药学院,沈阳,110016 |
| |
| 摘 要： | 目的观察局部用美洛昔康贴剂(Mel T)的抗炎作用及其对胃肠道的刺激性。方法采用二甲苯致腹腔毛细血管通透性增加法和二甲苯致耳肿胀法,角叉菜胶诱发足肿胀法以及完全佐剂诱导佐剂性关节炎等实验方法。结果Mel T局部粘贴小鼠20、105、mg/kg,明显抑制二甲苯所致的小鼠耳肿胀和二甲苯引起的皮肤毛细血管通透性的增加,大鼠足部粘贴14、7、3.5 mg/kg,明显抑制角叉菜胶致大鼠足肿胀;对AA大鼠原发性和继发性炎症均有抑制作用,且大鼠胃肠道粘膜出血和溃疡比Mel灌胃组少。结论Mel T有明显的抗炎作用,不良反应小于口服给药。
|
| 关 键 词： | 美洛昔康贴剂 抗炎 |
| 文章编号： | 1673-0070（2005）05-0019-04 |
| 收稿时间： | 2005-08-12 |
| 修稿时间： | 2005年8月12日 |
Experimental study of anti-inflammation on meloxicam picking |
| |
| WANG Cai-xia, ZHANG Hong-wu, WANG Rong-duan, et al CO. LTD, Shijiazhuang Group, Shijiazhuang , China; . College of Pharmacy, Shenyang Pharmaceutical University, Shenyang , China.Experimental study of anti-inflammation on meloxicam picking[J].Practical Pharmacy and Clinical Remedies,2006,9(1):19-22. |
| |
| Authors: | WANG Cai-xia ZHANG Hong-wu WANG Rong-duan CO LTD Shijiazhuang Group Shijiazhuang China; College of Pharmacy Shenyang Pharmaceutical University Shenyang China |
| |
| Institution: | WANG Cai-xia, ZHANG Hong-wu, WANG Rong-duan, et al CO. LTD, Shijiazhuang Group, Shijiazhuang 050051, China; 2. College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China) |
| |
| Abstract: | Objective To explore the anti-inflammation effect of meloxicam picking(MEL T).Methods The anti-inflammation actions of MEL T were investigated by the methods of xylene inducing auriculate tumefaction and increasing capillary permeability on mice,carrageenin inducing foot swelling on rat and primary and secondary paw edema of rats were induced by intradermal injection of complete Freund's adjuvant(CFA).Results Mel T(20、10、5 mg/kg) could inhibit the penetration of the blood vessel and swelling ears of mice.Mel T(14、7、3.5 mg/kg) could significantly inhibit swelling paws of rats by carrageenin and primary and secondary inflammation of CFA rats.Compared with Mel administered intragastrically(ig),Mel T had less side effects.Conclusion CFA Mel T has significant anti-inflammation effect and the side effect is less than that of meloxicam. |
| |
| Keywords: | Meloxicam picking Anti-inflammation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
