| 急性吗啡成瘾大鼠模型的建立 |
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| 引用本文： | 赵春禹,阎立昕,吕宁,张季叶,徐满英. 急性吗啡成瘾大鼠模型的建立[J]. 哈尔滨医科大学学报, 2001, 35(4): 257-258 |
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| 作者姓名： | 赵春禹 阎立昕 吕宁 张季叶 徐满英 |
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| 作者单位： | 1. 哈尔滨医科大学生理学教研室
2. 哈尔滨医科大学附属第二医院检验科 |
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| 基金项目： | 黑龙江省教委科研基金资助项目 (编号 0 0 8) |
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| 摘 要： | 目的 研究建立急性吗啡成瘾大鼠模型及对血液离子成份的影响。方法 将 6 0只大鼠随机分成吗啡成瘾组和对照组 ,比较成瘾组和对照组大鼠的戒断症状和血液分析。结果 成瘾组纳络酮诱发戒断症状结果是(34.82± 0 .5 3)次 ,对照组的结果是 (1.0 1± 0 .6 4)次 ,统计学处理显示组间差异很显著 (P <0 .0 1)。在血液离子成份上 ,统计学处理显示组间差异不显著 (P >0 .0 5 )。结论 急性吗啡成瘾大鼠模型的建立是切实可行的
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| 关 键 词： | 急性吗啡成瘾 大鼠 戒断 动物模型 建立 血液离子成份 |
| 文章编号： | 1000-1905(2001)04-0257-02 |
| 修稿时间： | 2001-03-06 |
Making the model quickly for morphinomania in rats |
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| Abstract: | Objective To make the model quickly for morphinomania in rats and to study the changes of K +, Na +, Cl -, Ca ++ in the rats blood before and after addication.Methods Sixty male Wistar rats were divided randomly into sham-operated group, morphinomania group. After five days, analysed the differences of withdrawal symptom.Results There were very significant differences between the groups in the withdrawal symptom and controls( P <0.01),but no significant differences in blood k+, Na +, Cl -, Ca ++ between experimental and control group ( P >0.05). Conclusion The model for morphinomania in rats can be safety, efficiently used in clinical trial according to this experiment. |
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| Keywords: | morphinomania rat model withdrawal |
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