Effect of Body Composition on Outcomes after Hepatic Resection for Hepatocellular Carcinoma |
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| Authors: | Shinji Itoh MD PhD Ken Shirabe MD PhD FACS Yoshihiro Matsumoto MD Shohei Yoshiya MD Jun Muto MD Norifumi Harimoto MD PhD Yo-ichi Yamashita MD PhD Toru Ikegami MD PhD FACS Tomoharu Yoshizumi MD FACS Akihiro Nishie MD PhD Yoshihiko Maehara MD PhD FACS |
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| Institution: | 1. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
2. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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| Abstract: | Purpose To evaluate the effect of body composition on outcomes after hepatic resection for patients with hepatocellular carcinoma (HCC). Methods We performed 190 hepatic resections for HCC and divided the patients into 2 groups on the basis of visceral fat area (VFA), assessed by computed tomographic measurement at the level of the umbilicus, into high VFA (H-VFA) (n = 106) and low VFA (L-VFA) (n = 84) groups. We compared the surgical outcomes between the two groups. Results L-VFA was significantly correlated with a lower body mass index, sarcopenia, lower serum albumin, and liver cirrhosis. There was no difference in the incidence of postoperative complications and mortality between the 2 groups. Patients in the L-VFA group had a significantly poorer prognosis than those in the H-VFA group in terms of both overall (P = 0.043) and recurrence-free (P = 0.001) survival. The results of multivariate analysis showed that sarcopenia rather than L-VFA was an independent and prognostic indicator after hepatic resection with HCC. Conclusions Body composition is an important factor affecting cancer outcomes after hepatic resection for HCC in Japan. |
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