肺积1号方抑制la-795肺腺癌小鼠移植瘤生长的实验研究

目的]探讨肺积1号方对la-795肺腺癌小鼠移植瘤生长的抑制作用。方法]给40只T739小鼠腋下注射肿瘤组织匀浆复制la-795小鼠肺癌模型,接种24 h后,按随机数字表法,将40只小鼠完全随机分为4组,每组10只,开始给药,4组分别为：对照组、顺铂DDP组、肺积1号方组、DDP＋肺积1号方组,观察各组小鼠一般状况、肿瘤大小、计算抑瘤率。结果]肺积1号方组小鼠体重增加最多,与对照组比较,差异有统计学意义（P〈0.01）,优于DDP组（P〈0.05）;各治疗组瘤重均显著低于对照组,抑瘤率DDP组、肺积1号方组、DDP＋肺积1号方组与对照组比较,差异有统计学意义（P〈0.01）,与DDP组比较,DDP＋肺积1号方组效果更好（P〈0.05）。肺积1号方与DDP合用有明显增效作用,抑瘤率大于单用DDP组。结论]肺积1号方能够明显抑制la-795肺腺癌小鼠移植瘤的生长,与DDP合用有明显增效作用。

Experiment on Tumor Inhibition with Feiji-1 Therapy in Mice with la-795 Lung Cancer

Objective] To investigate the anti-tumor effect of Feiji-1 therapy in mice with la-795 lung cancer.Methods]40 T739 mice under the regular injections of the organization of the replication la-795 mouse lung cancer model.After 24 hours,at random digital watch,40 mice were randomly divided into four groups,each group of 10,and began to take medicine：the control group,Cisplatin（DDP） group,Feiji-1 group and Feiji-1 with DDP group.General position was observed,the tumor size and detected tumor inhibition rates of the mice in each group.Results]There was a statistical significance between Feiji-1 group and the control group on gaining weight（P0.01）,and it was better than DDP group（compared with the control group,P0.05）;Compared with the control group,there were significant deviations in tumor inhibition rates of the mice in other three groups（P0.01）.Compared with DDP group,there was significant deviation in Feiji-1 with DDP group（P0.05）.Conclusion]Feiji-1 has certain inhibitive effect on the growth of la-795 lung cancer,enhancing the effect when it is used together with DDP.