初复治肺结核病人免疫功能指标变化的研究

目的]探讨肺结核病人的的免疫功能变化,以及相关指标在初复治、菌阴阳组之间是否存在差异。方法]采用流式细胞术检测外周血B细胞、T细胞亚群、NK细胞以及采用免疫透射比浊法测定IgG、IgA、IgM。结果]肺结核患者与正常人相比,CD4＋T细胞、CD8＋T细胞,CD4/CD8、IgG差异有统计学意义;初治菌阳组与正常对照组相比较,CD4＋T细胞、CD4/CD8的差异有统计学意义;初复治对CD4＋T细胞计数的影响有统计学意义。菌阴阳对各指标之间差异无统计学意义。结论]CD4＋T细胞对肺结核病人的预后有重要的影响。CD8＋T细胞及体液免疫在肺结核的细胞免疫功能中发挥重要作用。

Investigation of Immunity Function in Initially-treated and Retreated Tuberculosis Patients

Objective] To analyze difference between tuberculosis patients and normal people in immunity,and investigate the two factors（initially-treatment,retreatment;sputum smear positive,sputum smear negative）whether affect lung tuberculosis patients＇immunity or not.Methods]FCM was performed for analysis of B cells,T cells,and NK cells in peripheral whole blood of our cases.Immunity transmission turbidity was employed to detect IgA,IgG and IgM.Results]It had significant difference between tuberculosis patients and normal group in level of CD4＋T cell,CD8＋T cell,CD4/CD8 ratio（P0.05）.meanwhile,CD4＋T cell and CD4/CD8 ratio levelhad significant difference between the patients in initially-treated and smear positive group and in normal group,no difference was available among other groups.The factor（initially-treatment,retreatment）may have an effect on CD4＋T cell count（P0.05）.But the results between smear positive group and smear negative group had no difference（P0.05）in each test.Conclusion]CD4＋T cell may play an important role in outcomes of tuberculosis patients.CD8＋ T cell and humoral immunity play an important role in immune function of the tuberculosis patients.