Gene polymorphism in DNA repair genes XRCC1 and XRCC6 and association with colorectal cancer in Swedish patients |
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| Authors: | Jan Dimberg Marita Skarstedt Renate Slind Olsen Roland E. Andersson Andreas Matussek |
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| Affiliation: | 1. Department of Natural Science and Biomedicine, School of Health and Welfare, J?nk?ping University, J?nk?ping, Sweden;2. Division of Medical Diagnostics, Department of Laboratory Medicine, Region J?nk?ping County, J?nk?ping, Sweden;3. Division of Drug Research, Department of Medical and Health Sciences, Faculty of Health Sciences, Link?ping University, Link?ping, Sweden;4. Department of Surgery, Region J?nk?ping County, J?nk?ping, Sweden |
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| Abstract: | The DNA repair genes XRCC1 and XRCC6 have been proposed to participate in the pathological process of cancer by modulating the DNA repair capacity. This study evaluated the susceptibility of the single‐nucleotide polymorphisms (SNPs) XRCC1 (rs25487, G > A) and XRCC6 (rs2267437, C > G) to colorectal cancer (CRC) and their association with clinical parameters in Swedish patients with CRC. Using the TaqMan system, these SNPs were screened in 452 patients and 464 controls. No significant difference in genotype distribution was found between the patients and controls, or any significant association with cancer‐specific or disease‐free survival in patients. However, we showed that the carriers of allele A in XRCC1 (rs25487, G > A) were connected with a higher risk of disseminated CRC (Odds Ratio = 1.64; 95% Confidence Interval = 1.12–2.41, p = 0.012). |
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| Keywords: | DNA repair XRCC1 XRCC6 Single‐nucleotide polymorphism colorectal cancer |
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