−141C insertion/deletion polymorphism of the dopamine D2 receptor gene is associated with schizophrenia in Chinese Han population: Evidence from an ethnic group‐specific meta‐analysis |
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| Authors: | Xiaofeng Zhao MD Yinglin Huang MM Kaiyuan Chen MM Duolu Li MD Chao Han MM Quancheng Kan MD PhD |
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| Institution: | 1. Clinical Pharmacology Base, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;2. Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang, China;3. Mental Health Center, Shantou University Medical College, Shantou, China |
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| Abstract: | Accumulate evidence has implicated dopamine D2 receptor gene polymorphisms in the etiology of schizophrenia. A single nucleotide polymorphism, ?141C insertion/deletion (Ins/Del) (rs1799732), in the promoter region of the dopamine D2 receptor gene has been linked to schizophrenia; however, the data are inconclusive. This study investigated whether the ?141C polymorphism is associated with the risk of schizophrenia in different ethnic groups by performing a meta‐analysis. A total of 24 case–control studies examining the association between ?141C Ins/Del polymorphism and schizophrenia were identified according to established inclusion criteria. Significant association was revealed between ?141C Ins/Del polymorphism and schizophrenia risk in dominant genetic model (Ins/Ins + Ins/Del versus Del/Del) (odds ratio = 0.33, 95% confidence interval = 0.14–0.81, z = 2.41, P = 0.02) in Chinese Han but not in Caucasian, Japanese or India populations. Our results indicate that ?141C Ins/Del polymorphism might be a susceptibility factor for schizophrenia in Chinese Han population. |
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| Keywords: | − 141C ins/del dopamine D2 receptor meta‐analysis polymorphism schizophrenia |
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