淮北矿区尘肺结核病人耐药性的研究

目的 探讨淮北矿区尘肺结核病人的耐药情况，为临床制定化疗方案及预防措施提供科学依据。方法对活动性尘肺结核病人按《全国结核病细菌学检验规程》的要求，用改良罗氏法进行痰结核杆菌培养，培养阳性菌株采用绝对浓度间接法进行6种抗结核药物的耐药性测试。结果尘肺结核病人的痰结核分枝杆菌培养阳性55例，耐药38例，总耐药率为69．1％。初始耐药率为33．3％，耐多药率为11．1％；获得性耐药率为86．5％，耐多药率为45．9％。抗结核药的耐药顺位为R、H、Z、S、P、E。结论尘肺结核病人耐药情况不容乐观，应加强对尘肺结核病人尤其是耐药结核病人临床治疗的管理，制定合理的化疗方案至关重要。

Drug Resistance of the Silicosis Tuberculosis Patients in Huaibei Coalmine

[Objective] To explore the drug resistance of silicosis tuberculosis patients in HuaiBei coalmine and provide scientific evidence for the establishment of chemotherapy project.[Methods]According to the requirement in the National Regulation for the Tuberculosis Bacteriological Detection,reformed LJ method was applied for the cultivation of tuberculosis mycobacterium;absolute concentration indirect method was used to determine the drug resistance against 6 types of anti-tuberculosis drugs.[Results]55 cases were found positive,38 cases had drug resistance with a total drug resistance rate of 69.1%;preliminary drug resistance rate was 33.3%,multi drug resistance rate of which was 11.1%;acquired drug resistance rate was 86.5%;multi drug resistance rate of which was 45.9%;the order of drug resistance against tuberculosis drugs were R,H,Z,S,P and E.[Conclusion]The drug resistance situation among the silicosis tuberculosis patients is not satisfactory;clinical management should be improved especially on the drug resistant tuberculosis patients.