| 超氧阴离子对脑片谷氨酸释放的增强及依布硒的抑制 |
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| 引用本文： | 易 永,杨祥良,徐辉碧,赵西龙,张亨山,秦钰慧. 超氧阴离子对脑片谷氨酸释放的增强及依布硒的抑制[J]. 中国药理学与毒理学杂志, 1998, 12(2): 155-156 |
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| 作者姓名： | 易 永 杨祥良 徐辉碧 赵西龙 张亨山 秦钰慧 |
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| 作者单位： | 华中理工大学化学系，中国预防医学科学院环境卫生监测研究所毒理室 |
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| 摘 要： | 超氧阴离子对脑片谷氨酸释放的增强及依布硒的抑制易永杨祥良徐辉碧赵西龙１张亨山１秦钰慧１（华中理工大学化学系，武汉４３００７４；１中国预防医学科学院环境卫生监测研究所毒理室，北京１０００２１）兴奋性毒性是神经系统疾病中神经元损伤的一种重要病理机理，其特...
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| 关 键 词： | 大脑皮层；组织切片；谷氨酸；超氧化物；依布硒 |
| 收稿时间： | 1996-10-08 |
Glutamate release increased by superoxide anion radical and the protection of ebselen |
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| YI Yong， YANG Xiang-Liang， XU Hui-Bi， ZHAO Xi-Long, ZHANG Heng-Shan, QIN Yu-Hui. Glutamate release increased by superoxide anion radical and the protection of ebselen[J]. Chinese Journal of Pharmacology and Toxicology, 1998, 12(2): 155-156 |
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| Authors: | YI Yong， YANG Xiang-Liang， XU Hui-Bi， ZHAO Xi-Long ZHANG Heng-Shan QIN Yu-Hui |
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| Affiliation: | (Department of Chemistry, Huazhong University of Science &; Technology, Wuhan 430074；1. Institute of Environmental Health Monitoring, Chinese Academy of Preventive Medicine, Beijing 100021) |
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| Abstract: | ［3H］DL-Glutamate release increased by superoxide anion radical (O÷2) and the protection of ebselen were studied in rat cortical slices. Exposure of rat cortical slices to xanthine/xanthine oxidase, a O÷2 generating system, resulted in a marked increase in non-depolarized release of ［3H］DL-glutamate. Ebselen showed a blockade effect on the increase in glutamate release by O÷2. |
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| Keywords: | cerebral cortex tissue slices glutamates superoxide ebselen |
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