Study on of bioadhesive property of carbomer934 by a gamma camera in vivo

AIM: To study the bioadhesive property of carbomer934 indog alimentary tract.METHODS: Carbomer934 and ethylcellulose wereradiolabelled with technetium-99m; and gastrointestinalemptying rate of materials was measured using thetechnique of gamma scintigraphy.RESULTS: After oral administration, the maximum intestinalradioactivity of non-bioadhesive granules and bioadhesivegranules were observed in the second hour and the sixthhour respectively. Constants of stomach emptying rate ofnonadhesive granules, bioadhesive granules Ⅰ andbioadhesive granules Ⅱ were 0.774h-1, 0.265h-1 and0.321h-1 respectively on the base of gastric residualamount. Compared to nonadhesive material(ethylcellulose), the migration rate of adhesive material(carbomer934) was remarkably slower in dog alimentarycanal.CONCLUSION: lt is concluded that, in the dog, interactionsbetween gastrointestinal mucus layer and adhesive materialor nonadhesive material were significantly different.Carbomer934 had stronger in vivo bioadhesive property thanethylcellulose.