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Effect of hormone replacement therapy on the validity of the Friedewald equation in postmenopausal women: the postmenopausal estrogen/progestins interventions (PEPI) trial |
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| Authors: | Legault C Stefanick M L Miller V T Marcovina S M Schrott H G |
| Affiliation: | 1 Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC USA 2 Stanford Center for Research in Disease Prevention, Palo Alto, CA USA 3 George Washington University, Washington, DC USA 4 Department of Medicine, University of Washington, Seattle, WA USA 5 Department of Preventive Medicine and Environmental Health, University of Iowa College of Medicine, Iowa City, IA USA |
| Abstract: | The Friedewald equation is often used to estimate low-density lipoprotein cholesterol (LDL-C). Hormone therapy is known to raise triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) and alter lipid contents of lipoproteins. We compared Friedewald estimated LDL-C to measured LDL-C in PEPI participants on placebo or four different hormone treatment groups. At baseline, the 0.2 coefficient for triglyceride (TG) was accurate for all five treatment groups. Among women who took >80% of their pills and whose TG was <4.5 mmol/l (400 mg/dl), LDL-C was underestimated for 69–82% of the participants in the active treatment groups, compared to 50% in the placebo group. After 3 years of therapy, the TG coefficient that offered a better fit of the Friedewald equation in the active treatment groups was 0.39 for the equation in mmol/l (0.17 for the equation in mg/dl). Using this coefficient is clearly warranted for greater accuracy in research studies. |
| Keywords: | Postmenopause lipoproteins lipids LDL-C Friedewald hormone replacement therapy |
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