茵栀黄口服液灌肠治疗新生儿高胆红素血症32例

目的：在常规应用蓝光照射治疗新生儿高胆红素血症及对症处理的基础上,观察联用中药茵栀黄口服液灌肠疗法对新生儿高胆红素血症的疗效。方法：将62例患者随机分为2组：对照组30例,采用西医常规蓝光照射及对症处理;观察组32例,在对照组治疗基础上联用茵栀黄口服液保留灌肠,观察2组疗效。结果：观察组平均黄疸消退天数为（3.15±1.23）天,对照组平均黄疸消退天数为（6.62±1.72）天。2组黄疸消退时间存在显著性差异（P〈0.05）。治疗3天后对照组血清总胆红素（TBI L）水平降为（185.8±21.6）μmol/L,未结合胆红素（I BI L）下降为（159.4±20.4）μmol/L,观察组分别为（110.4±21.8）μmol/L,（96.4±18.7）μmol/L,2组比较有显著性差异（P〈0.01）。治疗7天后对照组TBI L水平降为（142.6±16.2）μmol/L,I BI L下降为（96.4±14.3）μmol/L,观察组分别为（64.2±19.6）μmol/L,（57.6±17.1）μmol/L,2组比较有显著性差异（P〈0.01）。结论：在常规蓝光照射及对症治疗基础上联用茵栀黄口服液灌肠治疗新生儿高胆红素血症,能明显缩短黄疸清退时间,迅速降低血清胆红素水平,疗效优于对照组。

Therapeutic Effect of YinZhiHuang Oral Liquids through Enema in Treating 32 Cases of Newborn Hyperbilirubinemia

Objective：To observe therapeutic effects of YinZhiHuang oral liquids in treating newborn hyperbilirubinemia through enema combined with blue light irradiation and symptomatic treatment.Method：62 patients with newborn hyperbilirubinemia were divided into two groups randomly.30 cases of control group were given symptomatic treatment and blue light irradiation therapy,32 cases of observation group were treated with YinZhiHuang oral liquids through enema combined with routine treatment given to control group,the effects of two groups were compared.Result：Average jaundice regression time in observation group was（3.15±1.23）days shorter than（6.62±1.72）days in control group with a significant difference（P0.05）.After 3 days of treatment,levels of total serum bilirubin（TBIL） and unconjugated bilirubin（IBIL） in observation group respectively decreased to（110.4±21.8）μmol/L and（96.4±18.7）μmol/L,superior to（185.8±21.6）μmol/L and（159.4±20.4）μmol/L in control group with a significant difference（P0.01）.After 7 days of treatment,TBIL and IBIL in observation group decreased to（64.2±19.6）μmol/L and（57.6±17.1）μmol/L,superior to（142.6±16.2）μmol/L and（96.4±14）μmol/L in control group with a significant difference（P0.01）.Conclusion：The combined therapy of YinZhiHuang oral liquid,blue light irradiation therapy and symptomatic treatment in treating newborn hyperbilirubinemia through enema can significantly reduce the jaundice regression time and quickly decrease level of serum bilirubin.The effects are better than the control group.