| 钙对染铅大鼠骨钙素、甲状旁腺激素及其受体表达的影响 |
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| 引用本文： | 胡雪琴,糜漫天. 钙对染铅大鼠骨钙素、甲状旁腺激素及其受体表达的影响[J]. 营养学报, 2007, 29(4): 328-331 |
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| 作者姓名： | 胡雪琴 糜漫天 |
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| 作者单位： | 第三军医大学营养与食品卫生学教研室,重庆,400038 |
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| 摘 要： | 目的:研究钙对铅染毒大鼠骨钙素(OC)、甲状旁腺激素(PTH)及其受体(PTHr1)表达的影响。方法:分别以纯净水和1.0g/L醋酸铅水饲喂Wistar大鼠,其中醋酸铅饲喂大鼠又分为正常饲料、高钙饲料和低钙饲料组。测定大鼠骨钙、骨铅、OC和PTH含量,并采用RT-PCR方法观察OC和PTHr1mRNA的表达。结果:铅处理降低了骨钙和血清OC的含量,抑制了OC mRNA的表达;但同时血清PTH的含量升高,PTHr1的表达增强;而高钙可以拮抗铅的这些作用,低钙则加剧了铅的上述效应。结论:补充膳食钙可减轻铅对大鼠骨骼的毒性作用。
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| 关 键 词： | 钙 铅 骨钙素 甲状旁腺激素及其受体 |
| 文章编号： | 0512-7955（2007）04-0328-04 |
| 修稿时间： | 2006-11-22 |
EFFECT OF CALCIUM ON THE EXPRESSION OF OSTEOCALCIN, PARATHORMONE AND PARATHORMONE RECEPTOR IN RAT EXPOSED TO LEAD |
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| HU Xue-qin,MI Man-tian. EFFECT OF CALCIUM ON THE EXPRESSION OF OSTEOCALCIN, PARATHORMONE AND PARATHORMONE RECEPTOR IN RAT EXPOSED TO LEAD[J]. Acta Nutrimenta Sinica, 2007, 29(4): 328-331 |
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| Authors: | HU Xue-qin MI Man-tian |
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| Affiliation: | Department of Nutrition and Food Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China |
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| Abstract: | Objective: To study the effect of calcium on osteocalcin(OC) and parathyroid hormone (PTH) in rat exposed to lead. Method: Wistar rats were randomly divided into control group, lead group, low-calcium lead group and high-calcium lead group. The content of calcium and lead in bone, OC and PTH of rat with different treatments were detected. At the same time, RT-PCR analysis was used to determine the expression of OC and PTHr1. Results: Lead decreased the content of calcium in bone and OC. The expression of OC was inhibited, and the level of PTH and the expression of PTHr1 increased, which could be enhanced by low calcium treatment, but high calcium treatment could antagonize these effects of lead. Conclusion: Supplementation of calcium in diet could extenuate the toxicity of lead on bone in rat. |
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| Keywords: | calcium lead osteocalcin parathormone parathormone receptor |
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