| 六神软膏的研制 |
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| 引用本文： | 符旭东,张宜,窦有业.六神软膏的研制[J].中国医院药学杂志,1999,19(10):596-598. |
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| 作者姓名： | 符旭东 张宜 窦有业 |
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| 作者单位： | 广州军区武汉总医院!武汉，430070，广州军区武汉总医院!武汉，430070，广州军区武汉总医院!武汉，430070，广州军区武汉总医院!武汉，430070，同济医科大学药学院 |
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| 摘 要： | 为满足临床需要，改变传统剂型。方法：对常用水溶性基质进行筛选，运用正交试验法优选基质最佳配方。采用消化后氧化－还原滴定的方法测定软膏中雄黄的含量。结果：选用甲基纤维素和丙二醇为软膏基质。制备工艺可行，制剂稳定，无刺激性。质量控制方法可靠，平均回收率为9904％，RSIJ为0.34％。结论：该制剂可用于临床。
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| 关 键 词： | 六神软膏 水溶性基质 正交试验法 雄黄 |
Study on preparation and quality control of liushen ointment |
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| Fu Xudong, Zhang Yi, Dou Youye, et al.Study on preparation and quality control of liushen ointment[J].Chinese Journal of Hospital Pharmacy,1999,19(10):596-598. |
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| Authors: | Fu Xudong Zhang Yi Dou Youye |
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| Institution: | Fu Xudong,Zhang Yi,Dou Youye,et al
(Wuhan General hospital of Guangzhou Area Command,Wuhan 430070) |
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| Abstract: | OBJECTIVE: To satisfy the needs of clinical therapy, and improve the traditional prepartion. METHODS: Optimizatematrix composition with orthogonal design test from the popular water-soluable matrix Xionghuang in Linshen ointment was deter-mined by oxidation-reduction titration after digestion. RESULTS: Liushea Ointment was prepared with MG450 and Propylenegycol.The prepartion technique was practicable, it is stable and has no irritation. The method of content determination was reiable. Theaverage recovery is 99.04 % with RSD 0. 34 %. CONCLUSION: It may be used in clinic. |
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| Keywords: | Liushen ointment water-soluable matrix orthogoal design xionghuang |
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