| 米托蒽醌白蛋白微球和联糖米托蒽醌白蛋白微球肝靶向性比较研究 |
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| 引用本文： | 张志荣,张奇志. 米托蒽醌白蛋白微球和联糖米托蒽醌白蛋白微球肝靶向性比较研究[J]. 中国医院药学杂志, 1999, 19(3): 140-142 |
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| 作者姓名： | 张志荣 张奇志 |
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| 作者单位： | 华西医科大学药学院,成都610041 |
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| 摘 要： | 目的：比较米托蒽醌白蛋白微球和联糖米托蒽醌白蛋白微球肝靶向性的优劣。方法：以小鼠为实验动物，以静脉注射给药后小鼠血浆及各器官中的米托蒽醌含量为指标。结果：联糖米托蒽醌白蛋白微球在肝中的分布高于米托蒽醌白蛋白微球，而且肝中米托蒽醌较高浓度的维持时间也更长。结论：联糖米托蒽醌白蛋白微球肝靶向性比米托蒽醌白蛋白微球好，但无统计学上的显著性差异。
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| 关 键 词： | 联糖米托蒽醌，白蛋白微球，肝靶向给药系统，高效液相色谱法 |
Comparison of liver targeting effect of mitoxantrone-bovine serum albumin-microspheres with galactosyl-mitoxantrone-bovine serum albumin-microspheres |
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| Zhang Zhirong,Zhang Qizhi. Comparison of liver targeting effect of mitoxantrone-bovine serum albumin-microspheres with galactosyl-mitoxantrone-bovine serum albumin-microspheres[J]. Chinese Journal of Hospital Pharmacy, 1999, 19(3): 140-142 |
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| Authors: | Zhang Zhirong Zhang Qizhi |
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| Abstract: | OBJECTIVE:To study the liver targeting effect of DHAQ BSA MS and Gal DHAQ BSA MS.METHODS:The liver targeting effect of DHAQ BSA MS and Gal DHAQ BSA MS were evaluated by measuring the drug concentration in each organ and plasma after i.v. administration via the tail vein of mice.RESULTS:The results showed that mean concentration of Gal DHAQ BSA MS in the liver was higher than that of HDAQ BSA MS,in addition,the Gal DHAQ BSA MS deposited a longer time in the liver with a higher drug concentration.CONCLUSIONS:There is no significant difference on statistics between DHAQ BSA MS and Gal DHAQ BSA MS. |
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| Keywords: | galactosyl mitoxantrone bovine serum albumin microspheres liver targeted drug delivery system HPLC |
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