丹参注射液对犬缺血心肌更新供血的影响

目的：探讨丹参注射液对犬缺血心肌更新供血的影响。方法：１２ 只犬随机分成丹参处理组（Ｄ 组） 和对照组（Ｃ 组），建立心肌梗塞模型，分别给予丹参注射液和生理盐水，共２１ ｄ，冠脉结扎前、后不同时间点行冠脉造影，并测量心肌血管面密度。结果：冠脉结扎后２ ｈ 和２２ ｄ 时Ｄ 组侧枝血管明显多于Ｃ组，第２２ 天时Ｄ组缺血区和梗塞区心肌毛细血管和供血血管面密度较Ｃ 组明显增加。结论：丹参注射液能促进犬冠脉侧枝循环的开放和形成，使缺血心肌达到更新供血，对缺血心肌具有保护作用。

Effect of salvia miltiorrhiza on angiogenesis in dogs with experimental acute myocardial infarction

OBJECTIVE:To evaluate the effect of salvia miltiorrhiza on angiogenesis in dogs with experimental acute myocardial infarction.METHODS:Twelve dogs were randomly divided into salvia miltiorrhiza(Danshen,D) group and control(C) group.Acute myocardial infarction model was built in all dogs.Salvia miltiorrhiza or saline was administered to two groups respectively for 21 days.Coronary angiography was performed before and after ligating coronary artery.The capillaries and distribution vessels density in tissue sections of myocardium were assessed.RESULTS:Angiography on hour 2 and day 22 after ligating coronary artery revealed significant augmentation of collateral vessels in D group versus controls,capillaries and distribution vessels density in ischemic and infarctive zone on day 22 revealed statistically significant augmentation in D group versus controls.CONCLUSIONS:Salvia miltiorrhiza might improve the opening and forming of coronary collateral circulation to ischemic myocardium in dogs and protect ischemic myocardium.