血管紧张素Ⅱ与胰岛素抵抗

血管紧张素Ⅱ是心血管系统的重要活性物质,起着调节机体水、电解质平衡,维持机体正常血压等作用.血管紧张素Ⅱ尚具有干扰胰岛素信号传递、抑制脂肪细胞分化、降低胰岛素靶组织对胰岛素的敏感性、诱导抑制胰岛素作用的细胞因子生成等多方面的作用,在胰岛素抵抗的发生和发展中起着重要作用.以血管紧张素Ⅱ为靶点改善胰岛素抵抗,治疗其相关疾病已成为当前研究的热点之一.

Angiotensin II and insulin resistance

Angiotensin II (Ang II) is a vasoactive peptide hormone that regulates blood pressure as well as fluid and electrolyte balance. Recently, accumulating evidence shows that Ang II plays an important role in the development of insulin resistance due to its multi-physical functions, such as interfering insulin signal transduction, inhibiting differentiation of pre-adipocytes, lowering the sensitivity of targeted tissues to insulin, and inducing the synthesis and release of cytokines with negative effects on insulin signal.