乌司他丁对泌尿系脓毒性休克患者血清PCT及 IL-6水平的影响

目的 :探讨乌司他丁对泌尿系脓毒性休克患者血清中前降钙素(procalcitonin,PCT)及白细胞介素-6(interleukin-6,IL-6)水平的影响。 方法 :选取30例泌尿系脓毒性休克患者,随机分为两组,每组15例,均给予常规抗休克和病因治疗。在此基础上,治疗组加用乌司他丁20万U溶于20 mL生理盐水中静脉注射,每天1次,连续3 d;对照组予以等量生理盐水作为安慰剂对照。另设正常对照组30例。应用双抗体夹心免疫发光法及双抗体夹心酶联免疫吸附法分别测定三组血清PCT及IL-6的含量。 结果 :PCT和IL-6水平在泌尿系脓毒性休克患者组显著高于正常对照组,且急性期显著高于恢复期,死亡组高于存活组。与安慰剂对照组相比,治疗组应用乌司他丁后,不同时相点的PCT、IL-6均明显降低(P<0.05,P<0.01)。 结论 :PCT和IL-6在泌尿系脓毒症发病机制中起预警作用,对该疾病的早期诊断及预后判断有重要应用价值。乌司他丁可降低泌尿系脓毒性休克患者血清PCT、IL-6水平,可改善泌尿系脓毒性休克患者的病情

Effect of Ulinastatin on Level of Serum Procalcitonin and IL-6 in Patients with Urological Septic Shock

Objective: To investigate the effect of Ulinnstatin on the level of serum procalcitonin and IL-6 in patients with urological septic shock. Method: Thirty patients with urological septic shock were randomLy divided into 2 groups-the test group and the control group. The control group accepted the general treatment, such as anti-shock, anti-infection and ICU. The test group accepted Ulfnastandn injection in addition. The levels of serum PCT and IL-6 in 30 patients with urological septic shock were serially measured at different time points by ICA and ELISA. And 20 health controls were included as well. Result: PCT and IL-6 level were significantly higher in patient group than health controls. PCT and IL-6 level in acute phase were higher than in recovery phase andand higher in the death group than in survival group.The PCT and IL-6 level in the test group were significantly lower than in the control group at every selected time points. Conclusion: PCT and IL-6 play important roles in the pathogenesis of sepsis and are valuable for early diagnosis and prognosis. Ulinastatin has protective effect on patients with Urological septic shock.