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0.5%马来酸噻吗洛尔溶液联合普萘洛尔治疗婴幼儿血管瘤的不良反应观察
引用本文:王佳,石静,王绪凯.0.5%马来酸噻吗洛尔溶液联合普萘洛尔治疗婴幼儿血管瘤的不良反应观察[J].中国口腔颌面外科杂志,2014(6):539-542.
作者姓名:王佳  石静  王绪凯
作者单位:中国医科大学附属口腔医院口腔颌面外科,辽宁省口腔医学研究所,辽宁沈阳110002
摘    要:目的 :局部涂抹0.5%马来酸噻吗洛尔溶液联合口服普萘洛尔与单纯口服普萘洛尔治疗婴幼儿血管瘤60例,评价其近期效果及不良反应。方法:随机抽取局部涂抹0.5%马来酸噻吗洛尔溶液联合口服普萘洛尔的患儿及单纯口服普萘洛尔治疗血管瘤的患儿各30例,用药前检查结果无异常,用药前、后1 h观察其心率、血压变化;服药后1个月观察有无呕吐、嗜睡、腹泻、局部皮肤反应、肢端发冷及低血糖症状等。采用SPSS 13.0软件包对数据进行统计学处理。结果:2组不良反应例数无显著差异,用药前、后1h内血压、心率变化不明显。结论:局部涂抹0.5%马来酸噻吗洛尔溶液联合口服普萘洛尔与单纯口服普萘洛尔的近期不良反应发生率相近,无严重不良反应发生。

关 键 词:婴幼儿血管瘤  马来酸噻吗洛尔  普萘洛尔  不良反应

Adverse effects of timolol maleate 0.5% solution combined with propranolol in treating infantile hemangiomas
WANG Jia,SHI Jing,WANG Xu-kai.Adverse effects of timolol maleate 0.5% solution combined with propranolol in treating infantile hemangiomas[J].China Journal of Oral and Maxillofacial Surgery,2014(6):539-542.
Authors:WANG Jia  SHI Jing  WANG Xu-kai
Institution:. (Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University; Liaoning Institute of Dental Research. Shenyang 110002, Liaoning Province, China)
Abstract:PURPOSE: To observe the adverse effects of using topical timolol maleate 0.5% solution in combination with oral propranolol and oral propranolol alone for infantile hemangiomas (IH). METHODS: A total of 60 infants with IH were included in this study, in which 30 patients were treated with topical timolol maleate 0.5% solution combined with oral propranolol and the remaining 30 cases received oral propranolol alone. All patients showed no abnormalities on physical examination before the treatment. The changes of heart rate and blood pressure were monitored before and lh after treatment. Potential side effects such as vomiting, lethargy, diarrhea, local skin reactions, cold extremities, and hypoglycemia were observed and recorded 1-month after treatment. The data was statistically analyzed with SPSS13.0 software package. RESULTS: There was no significant difference in adverse effects between the 2 groups; and the difference was not significant in heart rate and blood pressure before and 1 h after treatment. CONCLUSIONS: The adverse reactions were similar between patients receiving topical timolol maleate 0.5% solution in combination with oral propranolol and oral propranolol alone, no serious adverse events were found.
Keywords:Infantile hemangioma  Timolol maleate  Propranolol  Adverse effects
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