不同剂量阿托伐他汀对心房颤动患者hs-CRP、NO、IL-6、脂联素水平的影响

目的 观察不同剂量阿托伐他汀对房颤患者hs-CRP、NO、IL-6、脂联素水平的影响.方法 选取合肥市第三人民医院2012年12月至2014年2月住院的房颤患者80例,随机分为20 mg阿托伐他汀组和40 mg阿托伐他汀组,每组40例,观察两组患者治疗前后超敏C-反应蛋白（hs-C RP）、一氧化氮（NO）、白细胞介素-6（IL-6）、脂联素和左房内径的变化.结果 治疗前、后,20 mg阿托伐他汀组hs-CRP水平分别为（6.25±1.75）mg/L和（5.23±1.85）mg/L,IL-6水平分别为（14.53±2.32）ng/L和（13.02±2.12）ng/L;40 mg阿托伐他汀组hs-CRP水平分别为（6.45±1.65）mg/L和（4.25± 1.72）mg/L,IL-6水平分别为（14.65±2.42）ng/L和（11.12±1.25）ng/L.两组治疗后各项水平均明显降低,与治疗前比较差异有统计学意义（P＜0.05）,且40 mg阿托伐他汀组降低更明显,与20 mg阿托伐他汀组比较差异有统计学意义（P＜0.05）.20 mg阿托伐他汀组NO水平治疗前后分别为（26.30±1.65）mmol/L和（35.25±1.78）mmol/L,脂联素水平分别为（7.26±3.25）μg/L和（8.56±3.12）μg/L.两组治疗后各项水平均明显升高,与治疗前比较差异有统计学意义（P＜0.05）,且40 mg阿托伐他汀组升高更明显,与20 mg阿托伐他汀组比较差异有统计学意义（P＜0.05）.结论 大剂量阿托伐他汀能显著改变房颤患者血清炎症因子水平,且呈剂量依赖性.

Effects of high dosage Atorvastatin on hs-CRP,NO, IL-6, adiponectin in patients with atrial fibrillation

Objective To observe the different doses of Atorvastatin effects on patients with atrial fibrillation hs-CRP,NO,IL-6,adiponectin levels.Methods AF patients hospitalized in Third People＇s Hospital of Hefei from December 2012 to February 2014,80 patients were randomly divided into 20 mg Atorvastatin group and 40 mg Atorvastatin groups of 40 cases observed two groups of patients hypersensitive C-reactive protein （hs-CRP）,nitric oxide（NO）,interleukin-6（IL-6）,changes in adiponectin and changes in left atrial diameter before and after treatment.Results After treatment,20 mg Atorvastatin group hs-CRP levels before and after treatment was （6.25±1.75）mg/L,（5.23±1.85）mg/L,IL-6 levels before and after treatment was（14.53±2.32）ng/L,（13.02±2.12）ng/L.40 mg Atorvastatin group hs-CRP levels before and after treatment was （6.45±1.65）mg/L,（4.25±1.72）mg/L,IL-6 levels before and after treatment was （14.65±2.42）g/L,（11.12±1.25）g/L,before and after treatment were significantly lower （P〈0.05）,and 40 mg Atorvastatin reduced more significantly （P〈0.05）.20 mg Atorvastatin group before and after treatment was significantly higher NO （26.30±1.65）mmol/L,（35.25±1.78） mmol/L,adiponectin levels before and after treatment was（7.26±3.25）μg/L,（8.56±3.12）μg/L,before and after treatment were significantly increased （P〈0.05）,and 40 mg Atorvastatin group increased more significantly （P〈 0.05）.Conclusion Large dose Atorvastatin significantly alter the serum levels of inflammatory cytokines in patients with atrial fibrillation,a dose-dependent manner.