病理性自身抗体在狼疮肾炎中的致病作用

狼疮肾炎是系统性红斑狼疮的主要并发症之一，具有较高的死亡率和病死率。主要特征是体内出现大量的病理性抗体，然而这些抗体究竟是怎样引起肾脏损害的，至今仍未清楚。本文就免疫沉积和抗dsDNA抗体穿透引起狼疮肾炎的发病机制作一下回顾性总结

Pathogenic role of pathologic autoantibodies in lupus nephritis

Lupus nephritis is a major complication of systemic lupus erythematosus with high rate of morbidity and mortality,and which is charactered by large number of pathogenic autoantibodies. However, the question of how pathogenic autoantibodies contribute to renal damage is unresolved. Here, we review the evidence that the production of anti-DNA antibodies and the formation of glomerular immune deposits are important events in the pathogenesis of the disease.