| 移植肝细胞治疗大鼠急性肝衰竭的研究 |
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| 引用本文： | 张令志,汪伟业,叶宁川,屠士行,陈随法,秦洪义,陆贵有. 移植肝细胞治疗大鼠急性肝衰竭的研究[J]. 第二军医大学学报, 1986, 0(3) |
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| 作者姓名： | 张令志 汪伟业 叶宁川 屠士行 陈随法 秦洪义 陆贵有 |
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| 作者单位： | 长海医院传染病学教研室，长海医院传染病学教研室，长海医院传染病学教研室，长海医院传染病学教研室，长海医院传染病学教研室，长海医院病理科，长海医院病理科 进修生 |
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| 摘 要： | 本文报道,用D-氨基半乳糖(D-GAIN)诱发大鼠急性肝衰竭。于大鼠D-GaIN中毒后24h,腹腔移植同种完整肝细胞,提高活存率为48％。移植破碎肝细胞无效,而且出现凝血系统紊乱现象。本实验通过肝脏病理现察及~3H-胸隙嘧啶核苷(~3H-TdR)肝内掺入量测定结果表明,早期移植完整肝细胞,能阻止肝损害发展,并能刺激和促进病肝细胞再生、复原等作用。
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| 关 键 词： | 移植 急性肝衰竭 D-氨基半乳糖 肝细胞 治疗学 疾病模型 动物 大鼠 |
EFFECTS OF HEPATOCELLULAR TRANSPLANTATION ON ACUTE LIVER FAILURE IN RATS |
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| Zhang Lingzhi,et al. EFFECTS OF HEPATOCELLULAR TRANSPLANTATION ON ACUTE LIVER FAILURE IN RATS[J]. Former Academic Journal of Second Military Medical University, 1986, 0(3) |
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| Authors: | Zhang Lingzhi et al |
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| Abstract: | In this study, acute liver failure was induced in rats by d-galactosamine (D-GalN) injection. Intraperitoneal injection,24 h later, of viable syngeneic hepatocytes apparently increased the survival rate of these animals (48%), while transplantation of non-viable hepatocytes was ineffective and even showed a certain degree of clotting disorders.A microscopical observation of the liver specimens and estimation of DNA synthesis cy 3H-TdR suggest that viable hepatocellular transplantation may minimize the hepatic injury and promote hepatic cell regeneration. |
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| Keywords: | transplantation acute hepatic necrosis D-galactosamine hepatocyte disease models animal rats |
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