| 幽门螺旋杆菌感染后血清学改变的研究 |
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| 引用本文： | 王晶桐,刘玉兰.幽门螺旋杆菌感染后血清学改变的研究[J].中国消化内镜,2008(3):29-32. |
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| 作者姓名： | 王晶桐 刘玉兰 |
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| 作者单位： | 北京大学人民医院消化科;100044; |
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| 摘 要： | 目的 分析幽门螺旋杆菌感染后血清中所产生的H．pylori—IgG亚型、CagA—IgG亚型与临床转归的关系。
方法 以ELISA方法测定126位患者（42位消化性溃疡患者，84位慢性胃炎患者）血清H．pylori—IgG亚型和CagAIgG亚型。
结果 （1）H．pylori—IgG以IgG1和IgG2为主，IgG3和IgG4水平很低；CagA—IgG以IgG1和IgG3为主，IgG2水平很低，IgG4未测出；（2）消化性溃疡患者H．pylori—IgG3水平高于慢性胃炎患者，其他抗体水平无显著差异；（3）CagA—IgG阳性组患者的HP-IgG抗体及其亚型IgG1、IgG3均明显高于CagA-IgG阴性组，P〈0．01。
结论 消化性溃疡患者H．pylori—IgG3水平高于慢性胃炎患者，由于其固定补体的作用，可能在溃疡的发舟中具有一定作用。细菌是否表达CagA对宿主的免疫反应具有一定的影响，同临床转归可能相关。
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| 关 键 词： | 幽门螺旋杆菌 临床转归 抗体亚型 |
The Serological Changes after Helicobacter Pylori Infection |
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| WANG Jing-tong LIU Yu-lan Gastroenterology.The Serological Changes after Helicobacter Pylori Infection[J].Digestive Disease and Endoscopy,2008(3):29-32. |
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| Authors: | WANG Jing-tong LIU Yu-lan Gastroenterology |
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| Institution: | WANG Jing-tong LIU Yu-lan Gastroenterology Department of People\'s Hospital of Peking University,Beijing,100044,China |
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| Abstract: | Objective:This study is aiming to show the profile of IgG subclasses after H.pylori infection and its association with clinical outcomes.Methods:126 patiets(42 cases were peptic ulcer,82 cases were chronic gastritis) were included.H.pylori-IgG subtypes and CagA-IgG subtypes in sera were tested by ELISA.Results:1,IgG1 and IgG2 were dominant of H.pylori-IgG subtypes.The levels of H.pylori-IgG3 and IgG4 were very low.IgG1 and IgG3 were predominating in CagA-IgG,CagA-IgG4 was undetectable.2,Patients with peptic... |
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| Keywords: | Helicobacter Pylori Clinical outcomes IgG subtypes |
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